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Open AccessHuman leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma
Burkitt lymphoma (BL) is responsible for many childhood cancers in sub-Saharan Africa, where it is linked to recurrent or chronic infection by Epstein-Barr virus or Plasmodium falciparum. However, whether human l...
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Open AccessMosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa
In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosai...
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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-a...
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Article
Nonalcoholic fatty liver disease (NAFLD) detection and deep learning in a Chinese community-based population
We aimed to develop and validate a deep learning system (DLS) by using an auxiliary section that extracts and outputs specific ultrasound diagnostic features to improve the explainable, clinical relevant utili...
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Open AccessCirculating trans fatty acids are associated with prostate cancer in Ghanaian and American men
The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and...
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Open AccessTesting the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa
Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates of prostate cancer in...
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Open AccessChanges in lifestyles and depressive symptom among patients with chronic diseases during COVID-19 lockdown
This study aims to investigate the impact of COVID-19 lockdown on lifestyle behaviors and depressive symptom among patients with NCDs (noncommunicable diseases). We incorporated a COVID-19 survey to the WELL C...
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Open AccessSerum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer
There is evidence that tumor immunobiology and immunotherapy response may differ between African American and European American prostate cancer patients. Here, we determine if men of African descent harbor a u...
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Overall and central obesity and prostate cancer risk in African men
African men are disproportionately affected by prostate cancer (PCa). Given the increasing prevalence of obesity in Africa, and its association with aggressive PCa in other populations, we examined the relatio...
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Open AccessAssociations of park access, park use and physical activity in parks with wellbeing in an Asian urban environment: a cross-sectional study
Relationships between park access, park use, and wellbeing remain poorly understood. The objectives of this study were to investigate: (1) perceived and objective park access in relation to park use and physic...
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Article
Open AccessSoluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China
Elevated systemic levels of soluble cluster of differentiation 14 (sCD14) have been associated with gallbladder cancer (GBC), but the association with sCD14 levels within the gallbladder has not been investiga...
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Admixture/fine-map** in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes
Admixed populations are a resource to study the global genetic architecture of complex phenotypes, which is critical, considering that non-European populations are severely underrepresented in genomic studies....
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Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00786-2.
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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studie...
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Open AccessAuthor Correction: Circulating Levels of Inflammatory Proteins and Survival in Patients with Gallbladder Cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessExploring health and well-being in Taiwan: what we can learn from individuals’ narratives
Our aim was to explore the concepts of health and well-being from the point of view of the people experiencing them. Most of the efforts to understand these concepts have focused on disease prevention and trea...
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Open AccessRacial/ethnic- and county-specific prevalence of chronic hepatitis B and its burden in California
In the United States, the highest burden of chronic hepatitis B (CHB) and CHB-related liver cancer is in the state of California, primarily in the San Francisco (SF) Bay and Los Angeles (LA) areas. The aim of ...
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Open AccessMetabolomic profiles in breast cancer:a pilot case-control study in the breast cancer family registry
Metabolomics is emerging as an important tool for detecting differences between diseased and non-diseased individuals. However, prospective studies are limited.
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Open AccessCirculating Levels of Inflammatory Proteins and Survival in Patients with Gallbladder Cancer
Although inflammation is central to gallbladder cancer (GBC) development and proliferation, no study has systematically investigated circulating inflammatory proteins and patient survival. We aimed to examine ...
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Article
Open AccessAtlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use g...
