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Article
Open AccessComposite material consisting of microporous beta-TCP ceramic and alginate-dialdehyde-gelatin for controlled dual release of clindamycin and bone morphogenetic protein 2
The aim of this study was to produce a composite of microporous β-TCP filled with alginate-gelatin crosslinked hydrogel, clindamycin and bone morphogenetic protein (BMP-2) to prolong the drug-release behaviour...
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Article
Open AccessThe future of basic science in orthopaedics and traumatology: Cassandra or Prometheus?
Orthopaedic and trauma research is a gateway to better health and mobility, reflecting the ever-increasing and complex burden of musculoskeletal diseases and injuries in Germany, Europe and worldwide. Basic sc...
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Article
Open AccessThe acromioclavicular ligament shows an early and dynamic healing response following acute traumatic rupture
Symptomatic horizontal instability is clinically relevant following acute acromioclavicular joint dislocations. However, the intrinsic healing response is poorly understood. The present study sought to investi...
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Article
Open AccessExpression of xylosyltransferases I and II and their role in the pathogenesis of arthrofibrosis
Arthrofibrosis is a painful and restraining complication that occurs after about 10% of total knee arthroplasty and cruciate ligament surgery. The pathogenesis of arthrofibrosis has not yet been fully understo...
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Article
Open AccessViscoelasticity and histology of the human cartilage in healthy and degenerated conditions of the knee
There are many studies on osteoarthritis, but only a few studies deal with human arthrosis, comparing the mechanical properties of healthy and diseased samples. In most of these studies, only isolated areas of...
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Article
Immunohistochemical examination in arthrofibrosis of the knee joint
Arthrofibrosis (AF) is the result of increased cell proliferation and synthesis of matrix proteins (collagen I, III, and VI). Especially after invasive knee surgery, e.g., ligament reconstruction or knee repla...
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Article
In-vitro chondrogenic potential of synovial stem cells and chondrocytes allocated for autologous chondrocyte implantation — a comparison
The use of passaged chondrocytes is the current standard for autologous chondrocyte implantation (ACI). De-differentiation due to amplification and donor site morbidity are known drawbacks highlighting the nee...
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Article
Open AccessSustained release of rhBMP-2 from microporous tricalciumphosphate using hydrogels as a carrier
Tissue engineering and bone substitutes are subjects of intensive ongoing research. If the healing of bone fractures is delayed, osteoinductive materials that induce mesenchymal stem cells (MSCs) to form bone ...
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Article
Open AccessThe trans-well coculture of human synovial mesenchymal stem cells with chondrocytes leads to self-organization, chondrogenic differentiation, and secretion of TGFβ
Synovial mesenchymal stem cells (SMSC) possess a high chondrogenic differentiation potential, which possibly supports natural and surgically induced healing of cartilage lesions. We hypothesized enhanced chond...
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Article
Open AccessErratum to: Clinical trial and in-vitro study comparing the efficacy of treating bony lesions with allografts versus synthetic or highly-processed xenogeneic bone grafts
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Article
Open AccessClinical trial and in-vitro study comparing the efficacy of treating bony lesions with allografts versus synthetic or highly-processed xenogeneic bone grafts
Our study aim was to compare allogeneic cancellous bone (ACB) and synthetic or highly-processed xenogeneic bone substitutes (SBS) in the treatment of skeletal defects in orthopedic surgery.
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Article
Zoledronate induces bisphosphonate-related osteonecrosis of the jaw in osteopenic sheep
Bisphosphonate-related osteonecrosis of the jaw (BP-ONJ) occurs in 1 % of patients with medication-induced osteoporosis treated with bisphosphonates. Sheep are an established large animal model for investigati...
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Article
Novel approach to dynamic knee laxity measurement using capacitive strain gauges
Knee joint laxities are observed in patients after severe trauma to the joint, resulting in ligament tears. Specifically, injuries to the anterior cruciate ligament may cause a significant instability. The deg...
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Article
Open AccessMechanical tensile properties of the anterolateral ligament
In a noticeable percentage of patients anterolateral rotational instabilities (ALRI) remain after an isolated ACL reconstruction. Those instabilities may occur due to an insufficiently directed damage of anter...
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Article
Rotational laxity and collateral ligament laxity following total knee arthroplasty with rotating platform
The aim of this study was to evaluate laxity in knees with pre-operative (preop) valgus alignment compared to knees with pre-operative varus alignment after total knee arthroplasty (TKA).
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Article
Brace or no-brace after ACL graft? Four-year results of a prospective clinical trial
A controversial discussion is held on using stabilizing knee braces after anterior cruciate ligament (ACL) surgery. The current study investigated the influence of a stabilizing knee brace on results after ACL...
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Article
Indications for and results of arthroscopy in the arthritic knee: a European survey
The place of arthroscopic treatment in osteoarthritis of the knee has generated much controversy. A survey was initiated to collect the opinion of experienced surgeons.
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Article
Modular sleeves with ceramic heads in isolated acetabular cup revision in younger patients—laboratory and experimental analysis of suitability and clinical outcomes
One possibility in hip arthroplasty revisions is to combine a modular ceramic head with an adapter or sleeve in isolated acetabular cup replacement. This study consisted of an experimental part to analyse the ...
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Article
Revision of anterior cruciate ligament reconstruction with patellar tendon allograft and autograft: 2- and 5-year results
The most common failure reasons of an anterior cruciate ligament (ACL) graft are incorrect positioning of the drill channels and insufficient fixation. In many cases, one-stage revision with patellar tendon gr...
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Article
Graft-dependent differences in the ligamentization process of anterior cruciate ligament grafts in a sheep trial
The structural properties of the healing ligament are the determining factor for the stability of the reconstruction before, during, and after osseous integration of anterior cruciate ligament grafts. Over the...
