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Article
Open AccessEfficacy and safety of linagliptin in type 2 diabetes subjects at high risk for renal and cardiovascular disease: a pooled analysis of six phase III clinical trials
In patients with type 2 diabetes mellitus (T2DM), hypertension and microalbuminuria are predictive markers for increased renal and cardiovascular risk. This post hoc analysis of data from a global development pro...
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Article
Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006
Ependymoblastoma is a rare malignant brain tumor of early childhood. Data on clinical behavior and optimal treatment strategies are scarce. We report on 11 consecutively treated children with centrally confirm...
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Article
Natural history and management of low-grade glioma in NF-1 children
Pediatric neurofibromatosis type 1 (NF-1) patients are prone to develo** low-grade glioma (LGG). The HIT-LGG study 1996 aimed to observe the natural history of pediatric LGG and to postpone irradiation in yo...
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Article
Treatment options in childhood pontine gliomas
Pontine gliomas are the subgroup of brainstem gliomas with the worst prognosis. Controversial treatment approaches are discussed.
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Article
Melatonin Treatment in Obese Patients with Childhood Craniopharyngioma and Increased Daytime Sleepiness
Craniopharyngioma is a rare dysontogenetic benign tumor. Patients frequently suffer from endocrine deficiencies, sleep disturbances and obesity due to pituitary and hypothalamic lesions. A self-assessment dayt...
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Article
Longitudinal study on quality of life in 102 survivors of childhood craniopharyngioma
We longitudinally analysed functional capacity and quality of life (QoL) in 102 patients with a childhood craniopharyngioma during follow-up.
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Article
Functional capacity and body mass index in patients with sellar masses—cross-sectional study on 403 patients diagnosed during childhood and adolescence
We analyzed the impact of tumour localization and histology on functional capacity (FC) and body mass index (BMI) in children with sellar masses.