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Open AccessDe novo design of high-affinity binders of bioactive helical peptides
Many peptide hormones form an α-helix on binding their receptors1–4, and sensitive methods for their detection could contribute to better clinical management of disease5. De novo protein design can now generate b...
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Open AccessDe novo design of luciferases using deep learning
De novo enzyme design has sought to introduce active sites and substrate-binding pockets that are predicted to catalyse a reaction of interest into geometrically compatible native scaffolds1,2, but has been limit...
