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Article
Possible Predictive Markers of Response to Therapy in Esophageal Squamous Cell Cancer
The aim of the present study was to investigate the relationship between the intensity of biomarker expression and the response to radiochemotherapy in patients with advanced esophageal squamous cell cancer (E...
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Article
Open AccessGastrin-Releasing Peptide Receptor Antagonism Induces Protection from Lethal Sepsis: Involvement of Toll-like Receptor 4 Signaling
In sepsis, toll-like receptor (TLR)-4 modulates the migration of neutrophils to infectious foci, favoring bacteremia and mortality. In experimental sepsis, organ dysfunction and cytokines released by activated...
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Article
Open AccessThe Immunohistochemical Expression of Growth Hormone-Releasing Hormone Receptor Splice Variant 1 Is a Favorable Prognostic Marker in Colorectal Cancer
Hypothalamic growth hormone (GH)-releasing hormone (GHRH) regulates the release of GH from the pituitary gland. The receptors for GHRH (GHRH-R) are expressed predominantly in the pituitary. Recent evidence dem...
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Article
Ontogenetic development of corticotropin-releasing factor (CRF)-containing neural elements in the brain of the chicken during incubation and after hatching
In chicken embryos of different ages and in young chickens after hatching, neural elements reacting with antibodies generated against synthetic ovine corticotropin-releasing factor (CRF) were studied by means ...
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Article
The origin and ultrastructural characteristics of corticotropin-releasing factor (CRF)-immunoreactive nerve fibers in the posterior pituitary of the rat
A fine network of corticotropin-releasing factor (CRF)-immunopositive fibers was found in the posterior lobe of the pituitary of the rat. The intermediate and distal lobes were free of CRF-immunoreactivity. Va...
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Article
Localization of corticotropin-releasing factor-containing neurons in the brain of the domestic fowl
The corticotropin-releasing factor (CRF)-containing neurons were investigated in the brain of the domestic fowl by means of the peroxidase-antiperoxidase technique at the light-microscopic level. The detection...
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Article
Ultrastructural characteristics of immunolabelled, corticotropin releasing factor (CRF)-synthesizing neurons in the rat brain
The corticotropin releasing factor (CRF)-synthesizing perikarya and neural processes were detected at ultrastructural level in the hypothalamic paraventricular nucleus and in the median eminence of control and...
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Article
Comparison of the inhibition of histamine-and pentagastrin-stimulated gastric acid secretion by somatostatin in the cat
The effect of cyclic somatostatin on pentagastrin-and histamine-stimulated gastric acid secretion in conscious cats was studied. Evidence is produced that somatostatin competitively inhibits pentagastrin-stimu...
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Chapter
Prolactin Release Inhibiting and Stimulating Factors in the Hypothalamus
It is well established that secretion of prolactin by the pituitary gland in animals and humans is controlled by the hypothalamus by means of a hypothalamic neurohumor, prolactin release inhibiting factor (PIF...
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Chapter
Stimulatory and Inhibitory Analogs of Luteinizing Hormone Releasing Hormone (LHRH)
The isolation and the determination of the structure of porcine luteinizing hormone-releasing hormone (LHRH) (Fig. 1) in our laboratory (1–4) paved the way for its synthesis by our group (3,5) and by others (6...
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Chapter
Assays of Hypothalamic Releasing and Inhibiting Hormones
It is firmly established that the secretory activity of the pituitary gland is regulated by the hypothalamus of the brain by means of the releasing and inhibiting hormones which are elaborated by the nerve cel...
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Chapter
Structure-Activity Relationship of LH and FSH Releasing Hormone
During the past few years, several peptide hormones have been purified from hypothalamic tissue, their molecular structures determined and syntheses performed (Schally et al., 1973a). Studies carried out in vitro