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Article
Open AccessX-ray imageable, drug-loaded hydrogel that forms at body temperature for image-guided, needle-based locoregional drug delivery
Liver cancer ranks as the fifth leading cause of cancer-related death globally. Direct intratumoral injections of anti-cancer therapeutics may improve therapeutic efficacy and mitigate adverse effects compared...
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Article
Open AccessAuthor Correction: In vitro characterization of immune modulating drug-eluting immunobeads towards transarterial embolization in cancer
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Article
Open AccessIn vitro characterization of immune modulating drug-eluting immunobeads towards transarterial embolization in cancer
Hepatocellular carcinoma (HCC) is an aggressive liver cancer with limited effective treatment options. In this study, we selected TLR agonists imiquimod (IMQ), gardiquimod (GARD), GS-9620 and DSR 6434, and a s...
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Article
Open AccessComparative analysis of the immune response to RFA and cryoablation in a colon cancer mouse model
The immune response to radiofrequency ablation (RFA) and cryoablation (CRA) was characterized and compared in a colon cancer mouse model. All studies were conducted under a research protocol approved by the Na...
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Article
Electromagnetic Tracking and Optical Molecular Imaging Guidance for Liver Biopsy and Point-of-Care Tissue Assessment in Phantom and Woodchuck Hepatocellular Carcinoma
To evaluate an integrated liver biopsy platform that combined CT image fusion, electromagnetic (EM) tracking, and optical molecular imaging (OMI) of indocyanine green (ICG) to target hepatocellular carcinoma (...
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Article
Safety and Tolerability of Topotecan-Eluting Radiopaque Microspheres for Hepatic Chemoembolization in a Rabbit Preclinical Model
Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enz...
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Article
Open AccessOvarian teratoma in a woodchuck (Marmota monax) with hepatocellular carcinoma: radiologic and pathologic features
Teratomas are germ cell neoplasms composed of a wide variety of tissues. In the woodchuck, only one testicular teratoma has been described in the literature. The objective of this report was to describe the ra...
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Article
First Human Experience with Directly Image-able Iodinated Embolization Microbeads
To describe first clinical experience with a directly image-able, inherently radio-opaque microspherical embolic agent for transarterial embolization of liver tumors.
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Long Circulation and Tumor Accumulation
Nanoparticles have been employed in cancer management as vectors to deliver chemotherapeutic and/or imaging agents to tumors. Enhanced tumor accumulation occurs by virtue of the long circulation properties of ...
