5 Result(s)
-
Article
Open AccessIndividualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics
Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung cancer. Irinotecan therapy is...
-
Article
The Effect of St John’s Wort on the Pharmacokinetics of Docetaxel
St John’s wort (SJW), a herbal antidepressant, is commonly used by cancer patients, and its component hyperforin is a known inducer of the cytochrome P450 (CYP) isoenzyme 3A4. Here, the potential pharmacokinet...
-
Protocol
Pharmacogenetics of Membrane Transporters: A Review of Current Approaches
This chapter provides a review of the pharmacogenetics of membrane transporters, including ABC transporters and OATPs. Membrane transporters are heavily involved in drug disposition, by actively transporting s...
-
Article
The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers
Grape seed extract (GSE) has been shown to inhibit the cytochrome P450 (CYP) 2D6 isoenzyme in vitro. To determine the clinical effect of GSE on CYP2D6, the pharmacokinetic interaction between GSE and the sensi...
-
Article
Open AccessGBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior
Mania is a core feature of bipolar disorder (BD) that traditionally is assessed using rating scales. Studies using a new human behavioral pattern monitor (BPM) recently demonstrated that manic BD patients exhi...
