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  1. No Access

    Protocol

    Synthetic Biology Medicine and Bacteria-Based Cancer Therapeutics

    Spontaneous tumor regression following bacterial infection has been observed for hundreds of years. These observations along with anecdotal medical findings in 1890s led to the development of Coley’s “toxins,”...

    Jaehyung Lee, Andrew C. Keates, Chiang J. Li in RNA Scaffolds (2021)

  2. No Access

    Protocol

    In Vitro and In Vivo Gene Silencing by TransKingdom RNAi (tkRNAi)

    RNA interference (RNAi) is a potent and specific mechanism for eliminating the mRNA of specific genes. This gene silencing mechanism occurs naturally and is highly conserved from plants to human cells, holding...

    Shuanglin **ang, Andrew C. Keates, Johannes Fruehauf… in siRNA and miRNA Gene Silencing (2009)

  3. No Access

    Article

    Development of chronic colitis is dependent on the cytokine MIF

    The cytokine macrophage-migration inhibitory factor (MIF) is secreted by a number of cell types upon induction by lipopolysaccharide (LPS). Because colitis is dependent on interplay between the mucosal immune ...

    Ype P. de Jong, Ana C. Abadia-Molina, Abhay R. Satoskar, Kareem Clarke… in Nature Immunology (2001)