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Article
Open AccessNuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program
Differentiation of cardiac fibroblasts to myofibroblasts is necessary for matrix remodeling and fibrosis in heart failure. We previously reported that mitochondrial calcium signaling drives α-ketoglutarate-dep...
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Article
Propionyl-CoA metabolism links chromatin acylation to cardiac transcription
The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chroma...
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Chapter
Influence of Exercise on Cardiac Metabolism and Resilience
The numerous health benefits that derive from exercise are associated with remarkable changes in metabolism. With respect to the heart, exercise acutely increases cardiac energy demand, which, in concert with ...
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Article
Open AccessMitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
Fibroblast to myofibroblast differentiation is crucial for the initial healing response but excessive myofibroblast activation leads to pathological fibrosis. Therefore, it is imperative to understand the mech...
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Article
Open AccessIntegration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretation
Stable isotope-resolved metabolomics (SIRM) provides information regarding the relative activity of numerous metabolic pathways and the contribution of nutrients to specific metabolite pools; however, SIRM exp...
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Article
Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis
Extracellular flux (XF) analysis has become a mainstream method for measuring mitochondrial function in cells and tissues. Although this technique is commonly used to measure bioenergetics in intact cells, we ...
