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Article
Monitoring and evaluation of gully erosion in China's largest loess tableland based on SBAS-InSAR
Gully erosion is widespread in central China's ecologically fragile loess plateau. However, research on the monitoring and evaluation of large-scale erosion is scarce. Here, we collected 16 pairs of Sentinel-1...
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Article
Open AccessPSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders
Mutations in the adaptor protein PSTPIP1 cause a spectrum of autoinflammatory diseases, including PAPA and PAMI; however, the mechanism underlying these diseases remains unknown. Most of these mutations lie in...
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Article
Immediate post-procedure bridging with unfractioned heparin versus low molecular weight heparin in patients undergoing radiofrequency ablation for atrial fibrillation with an interrupted oral anticoagulation strategy
Many centers perform catheter ablation for atrial fibrillation (AF) with periprocedural interruption of oral vitamin K antagonists. In this scenario, the optimal post-procedural anticoagulation strategy is sti...
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Protocol
The Extended Family of Protein Tyrosine Phosphatases
In higher eukaryotes, the Tyr phosphorylation status of cellular proteins results from the coordinated action of Protein Tyrosine Kinases (PTKs) and Protein Tyrosine Phosphatases (PTPs). PTPs have emerged as h...
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Chapter and Conference Paper
Climate Change Adaptation Plan of Vitoria-Gasteiz, Spain
According to the International Panel on Climate Change, while majority of the efforts to combat climate change have been centred on mitigation, climate change adaptation is becoming crucial for effective and e...
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Article
Loss of the VHR dual-specific phosphatase causescell-cycle arrest and senescence
Protein tyrosine phosphatases regulate important processes in eukaryotic cells and have critical functions in many human diseases including diabetes to cancer1,2,3. Here, we report that the human Vaccinia H1-rela...
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Article
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
We report that a single-nucleotide polymorphism (SNP) in the gene (PTPN22) encoding the lymphoid protein tyrosine phosphatase (LYP), a suppressor of T-cell activation, is associated with type 1 diabetes mellitus ...
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Chapter
The dual-specific protein tyrosine phosphatase family
Dual-specificity protein phosphatases (DSPs) belong to the protein tyrosine phosphatase (PTP) superfamily since they contain the conserved motif HCX2GX2R and share the same tertiary structure. The DSP family c...
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Article
Tyrosine phosphorylation of VHR phosphatase by ZAP-70
The ZAP-70 tyrosine kinase is a key component of the signaling machinery for the T cell antigen receptor (TCR). Whereas recruitment and activation of ZAP-70 are relatively well understood, the proteins phospho...
