17 Result(s)
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High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
Naked mole rats seem almost entirely protected from develo** cancer, and this can now, at least in part, be explained by the production of a unique high-molecular-mass form of hyaluronan, a component of the ...
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Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax
The blind mole rat (BMR), Spalax galili, is an excellent model for studying mammalian adaptation to life underground and medical applications. The BMR spends its entire life underground, protecting itself from pr...
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SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
L1 retrotransposons are an abundant class of transposable elements that pose a threat to genome stability and may have a role in age-related pathologies such as cancer. Recent evidence indicates that L1s becom...
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Correction: Corrigendum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax
Nature Communications 5: Article number: 3966 (2014); Published online: 3 June 2014; Updated: 12 Aug 2015. In Fig. 2 of this Article, the CLOCK protein sequence of the blind mole rat (Spalax) was inadvertently...
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Open AccessLipidome determinants of maximal lifespan in mammals
Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationshi...
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L1 drives IFN in senescent cells and promotes age-associated inflammation
Retrotransposable elements are deleterious at many levels, and the failure of host surveillance systems for these elements can thus have negative consequences. However, the contribution of retrotransposon acti...
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Open AccessPublisher Correction: Lipidome determinants of maximal lifespan in mammals
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessNaked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
Naked mole-rat (NMR), the longest-living rodent, produces very-high-molecular-mass hyaluronan (vHMM-HA), compared to other mammalian species. However, it is unclear if exceptional polymer length of vHMM-HA is ...
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Reply to: Transformation of naked mole-rat cells
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Article
The role of retrotransposable elements in ageing and age-associated diseases
The genomes of virtually all organisms contain repetitive sequences that are generated by the activity of transposable elements (transposons). Transposons are mobile genetic elements that can move from one gen...
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Article
Open AccessEpigenetic aging of the demographically non-aging naked mole-rat
The naked mole-rat (NMR) is an exceptionally long-lived rodent that shows no increase of mortality with age, defining it as a demographically non-aging mammal. Here, we perform bisulfite sequencing of the bloo...
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Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance and possibly to the longevity of the longest-lived rodent—the naked mole-rat1,2. To study whether the benefits of HMM-HA coul...
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Open AccessIntegration of fluorescence in situ hybridization and chromosome-length genome assemblies revealed synteny map for guinea pig, naked mole-rat, and human
Descriptions of karyotypes of many animal species are currently available. In addition, there has been a significant increase in the number of sequenced genomes and an ever-improving quality of genome assembly...
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Open AccessEvolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle
Hyaluronic acid is a major component of extracellular matrix which plays an important role in development, cellular response to injury and inflammation, cell migration, and cancer. The naked mole-rat (Heterocepha...
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Open AccessInvariant γδTCR natural killer-like effector T cells in the naked mole-rat
The naked mole-rat (Heterocephalus glaber) is a long-lived rodent species showing resistance to the development of cancer. Although naked mole-rats have been reported to lack natural killer (NK) cells, γδ T cell-...
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Open AccessHyaluronidase inhibitor delphinidin inhibits cancer metastasis
Cancer remains a formidable global health challenge, with metastasis being a key contributor to its lethality. Abundant high molecular mass hyaluronic acid, a major non-protein component of extracellular matri...
