4 Result(s)
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Article
Open AccessHistone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3
Aging is linked to loss of the self-renewal capacity of adult stem cells. Here, we observed that human multipotent stem cells (MSCs) underwent cellular senescence in vitro. Decreased expression of histone deac...
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Article
Selective cell targeting and lineage tracing of human induced pluripotent stem cells using recombinant avian retroviruses
Human induced pluripotent stem cells (hiPSC) differentiate into multiple cell types. Selective cell targeting is often needed for analyzing gene function by overexpressing proteins in a distinct population of ...
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Article
Parallel generation of easily selectable multiple nephronal cell types from human pluripotent stem cells
Human pluripotent stem cells (hPSCs) provide a source for the generation of defined kidney cells and renal organoids applicable in regenerative medicine, disease modeling, and drug screening. These application...
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Article
Open AccessAn inactivating human TRPC6 channel mutation without focal segmental glomerulosclerosis
Transient receptor potential cation channel-6 (TRPC6) gene mutations cause familial focal segmental glomerulosclerosis (FSGS), which is inherited as an autosomal dominant disease. In patients with TRPC6-related F...
