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Individual sleep need is flexible and dynamically related to cognitive function
Given that sleep deprivation studies consistently show that short sleep causes neurocognitive deficits, the effects of insufficient sleep on brain health and cognition are of great interest and concern. Here w...
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Open AccessNo phenotypic or genotypic evidence for a link between sleep duration and brain atrophy
Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence ...
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Open AccessLongitudinal Modeling of Age-Dependent Latent Traits with Generalized Additive Latent and Mixed Models
We present generalized additive latent and mixed models (GALAMMs) for analysis of clustered data with responses and latent variables depending smoothly on observed variables. A scalable maximum likelihood esti...
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Open AccessCirculating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study
Circulating levels of the astrocytic marker S100B have been associated with risk of neuropsychiatric or neurological disorders. However, reported effects have been inconsistent, and no causal relations have ye...
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Open AccessBrain aging differs with cognitive ability regardless of education
Higher general cognitive ability (GCA) is associated with lower risk of neurodegenerative disorders, but neural mechanisms are unknown. GCA could be associated with more cortical tissue, from young age, i.e. brai...
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Article
Open AccessCognitive and hippocampal changes weeks and years after memory training
While immediate effects of memory-training are widely reported in young and older adults, less is known regarding training-dependent hippocampal plasticity across multiple intervention phases, and long-term ma...
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Open AccessAuthor Correction: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease
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Open AccessAsymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease
Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and...
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Open AccessCellular correlates of cortical thinning throughout the lifespan
Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration, yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology technique and gene ex...
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Open AccessWithin-session verbal learning slope is predictive of lifespan delayed recall, hippocampal volume, and memory training benefit, and is heritable
Memory performance results from plasticity, the ability to change with experience. We show that benefit from practice over a few trials, learning slope, is predictive of long-term recall and hippocampal volume ac...
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Open AccessElaboration Benefits Source Memory Encoding Through Centrality Change
Variations in levels of processing affect memory encoding and subsequent retrieval performance, but it is unknown how processing depth affects communication patterns within the network of interconnected brain ...
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Development of the P300 from childhood to adulthood: a multimodal EEG and MRI study
Maturation of attentional processes is central to cognitive development. The electrophysiological P300 is associated with rapid allocation of attention, and bridges stimulus and response processing. P300 is am...
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Open AccessThe corpus callosum as anatomical marker of intelligence? A critical examination in a large-scale developmental study
Intellectual abilities are supported by a large-scale fronto-parietal brain network distributed across both cerebral hemispheres. This bihemispheric network suggests a functional relevance of inter-hemispheric...
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Development of children born to mothers with mental health problems: subcortical volumes and cognitive performance at 4½ years
In a prospective longitudinal study, we investigated the outcomes of children born to mothers clinically referred for mental health problems during pregnancy (risk group, n = 17) relative to a control group (n = ...
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Normal variation in behavioral adjustment relates to regional differences in cortical thickness in children
Neuroanatomical correlates of developmental psychopathology such as attention deficit hyperactivity and conduct disorder have been identified. The majority of studies point to lesser gray matter in psychopatho...
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Neuroimaging Results Impose New Views on Alzheimer’s Disease—the Role of Amyloid Revised
Huge progress has been made in unraveling the mysteries of Alzheimer’s disease (AD), but we still do not understand the basic mechanisms that set off the cascade of pathological events. In May 2011, the Nation...
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Open AccessHippocampal volumes are important predictors for memory function in elderly women
Normal aging involves a decline in cognitive function that has been shown to correlate with volumetric change in the hippocampus, and with genetic variability in the APOE-gene. In the present study we utilize ...
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Effects of prenatal opiate exposure on brain development – a call for attention
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Interactive effects of APOE and CHRNA4 on attention and white matter volume in healthy middle-aged and older adults
In the present study, we investigated age-related changes in interactions between efficiency of neuronal repair mechanisms and efficiency of cholinergic neurotransmission in the context of attentional orientin...
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On the Topography of P3a and P3b Across the Adult Lifespan—A Factor-Analytic Study Using Orthogonal Procrustes Rotation
The purpose of this study was to investigate whether the activity distribution of P3a and P3b across the scalp changes with age or remains identical. 103 well-functioning adults, 20-90 years, performed a visua...
