21 Result(s)

Article

Multi-omics characterization of autophagy-related molecular features for therapeutic targeting of autophagy

Autophagy is a major contributor to anti-cancer therapy resistance. Many efforts have been made to understand and overcome autophagy-mediated therapy resistance, but these efforts have been unsuccessful in cli...

Mei Luo, Lin Ye, Ruimin Chang, Youqiong Ye, Zhao Zhang… in Nature Communications (2022)

Article

Regulatory networks in mechanotransduction reveal key genes in promoting cancer cell stemness and proliferation

Tumor-repopulating cells (TRCs) are cancer stem cell (CSC)-like cells with highly tumorigenic and self-renewing abilities, which were selected from tumor cells in soft three-dimensional (3D) fibrin gels with u...

Wei Huang, Hui Hu, Qiong Zhang, **an Wu, Fuxiang Wei, Fang Yang, Lu Gan… in Oncogene (2019)

Article

Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines

Human cancer cell lines are fundamental models for cancer research and therapeutic strategy development. However, there is no characterization of circular RNAs (circRNAs) in a large number of cancer cell lines.

Hang Ruan, Yu **ang, Junsuk Ko, Shengli Li, Ying **g, **aoyu Zhu… in Genome Medicine (2019)

Article

Regulatory network analysis reveals the oncogenesis roles of feed-forward loops and therapeutic target in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy. Aberrant expressed genes contribute to the development and progression of T-ALL. However, the regulation underlying their ...

Mengxuan **a, Qiong Zhang, Mei Luo, Pan Li, Yingxue Wang, Qian Lei… in BMC Medical Genomics (2019)

Article

Global analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers

The protein translational system, including transfer RNAs (tRNAs) and several categories of enzymes, plays a key role in regulating cell proliferation. Translation dysregulation also contributes to cancer deve...

Zhao Zhang, Youqiong Ye, **g Gong, Hang Ruan, Chun-Jie Liu… in Communications Biology (2018)

Article

Gene expression, regulation of DEN and HBx induced HCC mice models and comparisons of tumor, para-tumor and normal tissues

Hepatocellular carcinoma (HCC) is the leading cause of cancer mortality. Chemical and virus induction are two major risk factors, however, the potential molecular mechanisms of their differences remain elusive...

Qin Tang, Qi Wang, Qiong Zhang, Sheng-Yan Lin, Yanhong Zhu, **angliang Yang… in BMC Cancer (2017)

Article

Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy

Mutations in EYS are associated with autosomal recessive retinitis pigmentosa (arRP) and autosomal recessive cone-rod dystrophy (arCRD) however, the function of EYS and the molecular mechanisms of how these mutat...

Zhao**g Lu, Xuebin Hu, Fei Liu, Dinesh C. Soares, **liang Liu… in Scientific Reports (2017)

Article

Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis

Disseminated superficial porokeratosis (DSP) is a rare keratinization disorder of the epidermis. It is characterized by keratotic lesions with an atrophic center encircled by a prominent peripheral ridge. We i...

Jiuxiang Wang, Ying Liu, Fei Liu, Changzheng Huang, Shanshan Han… in Scientific Reports (2016)

Article

Transcription factor and miRNA co-regulatory network reveals shared and specific regulators in the development of B cell and T cell

The maturation process of lymphocyte was related to many blood diseases, such as lymphoma and lymphoid leukemia. Many TFs and miRNAs were separately studied in the development of B and T cells. In this study, ...

Ying Lin, Qiong Zhang, Hong-Mei Zhang, Wei Liu, Chun-Jie Liu… in Scientific Reports (2015)

Article

Scoring the correlation of genes by their shared properties using OScal, an improved overlap quantification model

Scoring the correlation between two genes by their shared properties is a common and basic work in biological study. A prospective way to score this correlation is to quantify the overlap between the two sets ...

Hui Liu, Wei Liu, Ying Lin, Teng Liu, Zhaowu Ma, Mo Li… in Scientific Reports (2015)

Article

MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction

Myocardial infarction (MI) is a leading cause of death in the world and many genes are involved in it. Transcription factor (TFs) and microRNAs (miRNAs) are key regulators of gene expression. We hypothesized t...

Ying Lin, Vusumuzi Leroy Sibanda, Hong-Mei Zhang, Hui Hu, Hui Liu… in Scientific Reports (2015)

Article

Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study

A variety of species and experimental designs have been used to study genetic influences on alcohol dependence, ethanol response, and related traits. Integration of these heterogeneous data can be used to prod...

Zhongming Zhao, An-Yuan Guo, Edwin JCG van den Oord, Fazil Aliev… in BMC Genomics (2012)

Article

miRNASNP: a database of miRNA related SNPs and their effects on miRNA function

**g Gong, Yin Tong, Hong-Mei Zhang, An-Yuan Guo in BMC Bioinformatics (2012)

Article

Transcriptional profile of Taxus chinensis cells in response to methyl jasmonate

Methyl jasmonate (MeJA) has been successfully used as an effective elicitor to enhance production of taxol and other taxanes in cultured Taxus cells. However the mechanism of MeJA-mediated taxane biosynthesis rem...

Shu-tao Li, Peng Zhang, Meng Zhang, Chun-hua Fu, Chun-fang Zhao… in BMC Genomics (2012)

Article

A Novel microRNA and transcription factor mediated regulatory network in schizophrenia

Schizophrenia is a complex brain disorder with molecular mechanisms that have yet to be elucidated. Previous studies have suggested that changes in gene expression may play an important role in the etiology of...

An-Yuan Guo, **gchun Sun, Peilin Jia, Zhongming Zhao in BMC Systems Biology (2010)