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  1. No Access

    Article

    Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination

    Antibody affinity maturation relies on activation-induced cytidine deaminase (AID)-dependent somatic hypermutation (SHM) of immunoglobulin (Ig) loci. Class switch recombination (CSR) can in parallel occur betw...

    Amélie Bonaud, Fabien Lechouane, Sandrine Le Noir… in Nature Communications (2015)

  2. Article

    Open Access

    WHIM Syndrome-linked CXCR4 mutations drive osteoporosis

    WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report a decrease in bone mineral density in 25% of WHIM patients and bone defects leading to osteoporosis in a WHIM mo...

    Adrienne Anginot, Julie Nguyen, Zeina Abou Nader, Vincent Rondeau… in Nature Communications (2023)

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