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Open AccessTreatments for Chronic Kidney Disease: A Systematic Literature Review of Randomized Controlled Trials
Delaying disease progression and reducing the risk of mortality are key goals in the treatment of chronic kidney disease (CKD). New drug classes to augment renin–angiotensin–aldosterone system (RAAS) inhibitor...
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Article
Open AccessVertebral fracture as a risk factor for self-harm: a retrospective cohort study
The prevention of self-harm is an international public health priority. It is vital to identify at-risk populations, particularly as self-harm is a risk factor for suicide. This study aims to examine the risk ...
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Article
Open AccessAntibiotic use and the risk of rheumatoid arthritis: a population-based case-control study
Antibiotic-induced disturbances of the human microbiota have been implicated in the development of chronic autoimmune conditions. This study aimed to assess whether antibiotic use is associated with the onset ...
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Article
Open AccessComorbidities in polymyalgia rheumatica: a systematic review
Comorbidities are known to exist in many rheumatological conditions. Polymyalgia rheumatica (PMR) is a common inflammatory rheumatological condition affecting older people which, prior to effective treatment, ...
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Article
Open AccessRisk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study
An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lower...
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Article
Open AccessRisk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study
Glucocorticoids are associated with increased fracture risk and are the mainstay of treatment in polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). However, fracture risk in these conditions has not ...
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Article
Open AccessGout and subsequent erectile dysfunction: a population-based cohort study from England
An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level ...