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Reference Work Entry In depth
Biopsy of the Sentinel Lymph Node
Lymphatic map** and sentinel lymph node biopsy are standard components of the care of newly diagnosed patients with clinically localized intermediate- and high-risk melanoma. The procedures are the culminati...
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Reference Work Entry In depth
Classification and Histopathology of Melanoma
While a melanoma may be suspected clinically, a definitive diagnosis usually requires pathologic assessment of a tissue biopsy. Pathologic diagnosis of melanoma requires evaluation of changes in the architectu...
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Living Reference Work Entry In depth
Classification and Histopathology of Melanoma
While a melanoma may be suspected clinically, a definitive diagnosis usually requires pathologic assessment of a tissue biopsy. Pathologic diagnosis of melanoma requires evaluation of changes in the architectu...
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Living Reference Work Entry In depth
Biopsy of the Sentinel Lymph Node
Lymphatic map** and sentinel lymph node biopsy are standard components of the care of newly diagnosed patients with clinically localized intermediate- and high-risk melanoma. The procedures are the culminati...
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Article
High response rate to PD-1 blockade in desmoplastic melanomas
Immune checkpoint blockade with anti-PD-1 or anti-PD-L1 agents produces a high response rate in patients with desmoplastic melanoma.
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Article
Open AccessCutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors
BRAF inhibitors are highly effective therapies for the treatment of BRAFV600-mutated melanoma, with the main toxicity being a variety of hyperproliferative skin conditions due to paradoxical activation of the mit...
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Article
Open AccessMolecular enhancement of sentinel node evaluation
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Article
MSLT-I—response of clinical trial investigators
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Article
Pilot Study on “Pericytic Mimicry” and Potential Embryonic/Stem Cell Properties of Angiotropic Melanoma Cells Interacting with the Abluminal Vascular Surface
The interaction of tumor cells with the tumor vasculature is mainly studied for its role in tumor angiogenesis and intravascular metastasis of circulating tumor cells. In addition, a specific interaction of tu...
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Article
Reply to Letter to the Editor “Lymphoedema in the Observation and Biopsy Arms of MSLT-1” by Thomas, J Meirion (ASO-2011-04-0666)
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Article
EANM-EORTC general recommendations for sentinel node diagnostics in melanoma
The accurate diagnosis of a sentinel node in melanoma includes a sequence of procedures from different medical specialities (nuclear medicine, surgery, oncology, and pathology). The items covered are presented...
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Chapter
Dendritic Cells in Tumor-Draining Lymph Nodes
Dendritic cells are neither the most obvious nor the most abundant cells in lymph nodes, but are certainly among the most immunologically influential, acting primarily as highly potent professional antigen-pre...
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Article
Tumour-induced immune modulation of sentinel lymph nodes
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Article
The rationale for sentinel-node biopsy in primary melanoma
The value of sentinel-node biopsy for the management of localized primary melanoma has been questioned. In this Viewpoint, the authors discuss the data that support the routine use of sentinel-node biopsy, and...
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Article
Tumour–induced immune modulation of sentinel lymph nodes
In most patients with melanoma who develop metastases, the regional lymph nodes are the first organs to be affected.
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Article
Immune responses in the draining lymph nodes against cancer: Implications for immunotherapy
Regional lymph nodes are the first site for melanoma metastases. The sentinel node (SN), on the direct lymphatic drainage pathway, which usually harbors first metastases, demonstrates significant suppression i...
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Article
Invited commentary on “Decorative sentinel lymph node – a new entity?” by Vandeweyer and Van De Casseye
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Chapter
Accurate Evaluation of Nodal Tissues for the Presence of Tumor is Central to the Sentinel Node Approach
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Chapter
Study of Sentinel Lymph Nodes in the Staging of Malignant Neoplasms
Surgeons have long appreciated the significance of lymph node metastases to cancer prognosis. As far back as the 6th century, Actus of Amida observed that “malignant phlegmons” develop in the armpits of advanc...
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Article
The place of lymphatic map** and sentinel node biopsy in oncology
The techniques of sentinel lymphatic map** (LM) and sentinel lymph node biopsy (SLNB) have become almost routine for the staging of clinically node-negative patients with high-risk cutaneous melanoma. The te...