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Article
Patient preference for deferasirox film-coated versus dispersible tablet formulation: a sequential-design phase 2 study in patients with thalassemia
Iron chelation therapy (ICT) is the mainstay of treatment in patients with thalassemia requiring blood transfusions. This phase 2 JUPITER study evaluated patient preference between film-coated tablet (FCT) and...
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Article
Magnitude of cumulative iron overload correlates with the severity of anemia in untreated non-transfusion-dependent β-thalassemia
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Article
Anhidrosis associated with long-term use of hydroxyurea in a patient with myeloproliferative neoplasm
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Article
Deep venous thrombosis and pulmonary embolism after COVID-19 mRNA vaccination
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Article
Morbidity-free survival and hemoglobin level in non-transfusion-dependent β-thalassemia: a 10-year cohort study
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Article
Digital thermography and vascular involvement in β-thalassemia intermedia
Beta-thalassemia intermedia (β-TI) is associated with vascular dysfunction. We used digital thermal monitoring (DTM), a non-invasive tool that evaluates vascular function based on changes in fingertip temperat...
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Article
Variations in hemoglobin level and morbidity burden in non-transfusion-dependent β-thalassemia
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Article
Open AccessAntiphospholipid Antibodies in Inflammatory and Autoimmune Rheumatic and Musculoskeletal Diseases Beyond Lupus: A Systematic Review of the Available Evidence
The diagnosis of antiphospholipid syndrome (APS) requires the presence of thrombosis and/or recurrent miscarriages along with one or more anti-phospholipid antibodies (aPL). The role of aPL has been largely in...
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Chapter
Hepatocellular Carcinoma in Lebanon and Its Association with Thalassemia
Liver cancers are relatively uncommon in Lebanon ranking as the 18th most common type of tumor. Liver cancer rates have however been rising both in Lebanon and globally. Hepatocellular carcinoma (HCC) in Leban...
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Chapter
An Overview of Hepatocellular Carcinoma (HCC) in Lebanon: A Focus on Hepatitis B- and Thalassemia-Related HCC
Although incidence of hepatocellular carcinoma (HCC) is relatively low, it remains a deadly disease with a dismal prognosis. In Lebanon, most cases arise from chronic hepatitis B (HBV) and hepatitis C virus (H...
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Article
Thalassemia in the emergency department: special considerations for a rare disease
Thalassemia is characterized by a defect in the synthesis of one or more of the globin subunits of hemoglobin. This defect results in imbalance in the α/β-globin chain ratio, ineffective erythropoiesis, chroni...
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Article
Beta Thalassemia: New Therapeutic Options Beyond Transfusion and Iron Chelation
Hemoglobinopathies are among the most common monogenic diseases worldwide. Approximately 1–5% of the global population are carriers for a genetic thalassemia mutation. The thalassemias are characterized by aut...
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Article
Less ‘reds’ more ‘blues’: hemoglobin level and depression in non-transfusion-dependent thalassemia
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Article
Open AccessPatient-reported outcomes from a randomized phase II study of the deferasirox film-coated tablet in patients with transfusion-dependent anemias
Adherence to long-term chelation therapy in transfusion-dependent patients is critical to prevent iron overload-related complications. Once-daily deferasirox dispersible tablets (DT) have proven long-term effi...
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Article
Management of Non-Transfusion-Dependent Thalassemia: A Practical Guide
Despite their transfusion-independence, non-transfusion-dependent thalassemia (NTDT) patients experience a variety of serious clinical complications that require prompt and comprehensive management. Transfusio...
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Article
Open AccessIdentification and key management of non-transfusion-dependent thalassaemia patients: not a rare but potentially under-recognised condition
Patients with non-transfusion-dependent thalassaemia (NTDT) have a genetic defect or combination of defects that affect haemoglobin synthesis, but which is not severe enough to require regular blood transfusio...
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Chapter
B-Cell Targeted Therapies in Autoimmune Cytopenias and Thrombosis
Ever since the advent of Rituximab and subsequently the emergence of other compounds targeting B cells, a cornucopia of medical applications have been found for this family of compounds. After their establishm...
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Article
Open AccessDeferasirox effectively reduces iron overload in non-transfusion-dependent thalassemia (NTDT) patients: 1-year extension results from the THALASSA study
Patients with non-transfusion-dependent thalassemia (NTDT) often develop iron overload that requires chelation to levels below the threshold associated with complications. This can take several years in patien...
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Article
Livedoid vasculopathy in a patient with lupus anticoagulant and MTHFR mutation: treatment with low-molecular-weight heparin
Livedoid vasculopathy is characterized by painful purpuric lesions on the extremities which frequently ulcerate and heal with atrophic scarring. For many years, livedoid vasculopathy has been considered to be ...
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Article
Serum ferritin levels and endocrinopathy in medically treated patients with β thalassemia major
The association between iron overload indices and pathology of the heart and liver in transfusion-dependent patients with β thalassemia major (TM) has been extensively studied. Nonetheless, data on endocrine d...
