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Article
Prediction of the First-Pass Metabolism of a Drug After Oral Intake Based on Structural Parameters and Physicochemical Properties
The oral first-pass metabolism is a crucial factor that plays a key role in a drug’s pharmacokinetic profile. Prediction of the oral first-pass metabolism based on chemical structural parameters can be useful ...
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Article
Open AccessDetermination of indoxyl sulfate by spectrofluorimetric method in human plasma through extraction with deep eutectic solvent
A rapid and efficient analytical method was established to quantify indoxyl sulfate (IS) in plasma through extraction technique with a deep eutectic solvent (DES) and spectrofluorimetric method. DES (choline c...
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Article
Neural Network Models for Predicting Solubility and Metabolism Class of Drugs in the Biopharmaceutics Drug Disposition Classification System (BDDCS)
The biopharmaceutics drug disposition classification system (BDDCS) categorizes drugs into four classes on the basis of their solubility and metabolism. This framework allows for the study of the pharmacokinet...
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Article
Open AccessDevelo** an analytical method for quantification of trientine based on modified silver nanoparticles
Trientine or (N,N´-bis(2-aminoethyl)-1,2-ethanediamine (TETA) is a copper chelator and used in Wilson’s disease, is aliphatic amine that does not have UV absorbing groups. In this study, the modified silver na...
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Article
The anticancer impacts of N, S donor pyrazole based ligand and its Co(III) and Cu(II) complexes on breast cancer cells
The development of suitable compounds for the effective treatment of cancer is highly demanded. Inorganic complexes based on cobalt and copper centers have revealed a great potential for the treatment of vario...
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Article
Copper (II) complexes based bis(pyrazolyl)borate derivatives as efficient anticancer agents: synthesis, characterization, X-ray structure, cytotoxicity, molecular docking and QSAR studies
Copper-based complexes have various applications in the current era, particularly in the field of pharmaceutical and biochemistry. Four types of the bis(pyrazolyl) borate-based ligands that abbreviated K[H2B(Pz)2
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Article
Effects of Surfactant and Polymer on Thermodynamic Solubility and Solution Stability of Carbamazepine–Cinnamic Acid Cocrystal
This study was aimed at evaluating the solubility and solution stability of a cocrystal form of carbamazepine with cinnamic acid in the presence of sodium dodecyl sulfate (SDS) as surfactant and polyvinyl pyrr...
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Article
Copper (II) complexes with N, S donor pyrazole-based ligands as anticancer agents
A group of bidentate nitrogen and sulfur donor pyrazole derivative ligands abbreviated as Na[RNCS(Pz)], Na[RNCS(PzMe2)], Na[RNCS(PzMe3)], Na[RNCS(PzPhMe)], Na[RNCS(PzPh2)], where (R = Et, Ph), and their Cu (II) c...
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Article
Open AccessComparison of various methods for validity evaluation of QSAR models
Quantitative structure–activity relationship (QSAR) modeling is one of the most important computational tools employed in drug discovery and development. The external validation of QSAR models is the main poin...
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Article
Predicting the Drug Clearance Pathway with Structural Descriptors
The clearance, by renal elimination or hepatic metabolism, is one of the most important pharmacokinetic parameters of a drug. It allows the half-life, bioavailability, and drug–drug interactions to be predicte...
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Article
Spectrofluorimetric determination of indoxyl sulfate in human plasma after salting-out assisted liquid–liquid extraction
A simple analytical method was developed to quantify indoxyl sulfate (InS) in plasma using a salting-out assisted liquid–liquid extraction and spectrofluorimetry. Plasma samples were deproteinized by acetonitr...
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Article
New aspects of deep eutectic solvents: extraction, pharmaceutical applications, as catalyst and gas capture
Deep eutectic solvents (DESs) have widely applied in various fields. Given this and that DESs has low toxicity and are green solvents, new aspects of these solvents have been recently considered by researchers...
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Article
Prediction of the Oral Bioavailability Correlation Between Humans and Preclinical Animals
Experimental determination of a drug's oral bioavailability in humans is cost and time consuming; therefore, is usually performed on preclinical animals. It is believed that animal data are predictive of human...
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Article
Develo** an Analytical Method Based on Graphene Quantum Dots for Quantification of Deferiprone in Plasma
In the world of nanotechnology, graphene quantum dots (GQDs) have been considerably employed in numerous optical sensing and bioanalytical applications. Herein, a simple and cost-efficient methodology was deve...
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Article
Salting-out liquid–liquid microextraction to the determination of mycophenolic acid in plasma samples
This study aimed to develop a determination method of mycophenolic acid (MPA) in biological samples using salting-out liquid–liquid microextraction from human plasma samples based on the formation of a fluores...
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Article
Coenzyme Q10 in association with metabolism-related AMPK/PFKFB3 and angiogenic VEGF/VEGFR2 genes in breast cancer patients
Low levels of coenzyme Q10 (CoQ10) have been reported in the circulation of patients with breast cancer, particularly in metastatic features. Our objective was to study the correlation between plasma levels of...
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Article
Ionic Liquid Forms of Carvedilol: Preparation, Characterization, and Solubility Studies
Pharmaceutically active compounds (API) in solid form have several disadvantages which may include polymorphism, poor solubility, and low bioavailability. To overcome these issues, API-based ionic liquids have...
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Article
Open AccessThe effects of Berberis vulgaris consumption on plasma levels of IGF-1, IGFBPs, PPAR-γ and the expression of angiogenic genes in women with benign breast disease: a randomized controlled clinical trial
The present study was designed to investigate the effects of Berberis vulgaris (BV) juice consumption on plasma levels of insulin-like growth factor (IGF-1), IGF-binding proteins (IGFBPs), and the expression of P...
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Article
Open AccessDevelo** a high-performance liquid chromatography fast and accurate method for quantification of silibinin
Silibinin is an antioxidant agent and is shown to have anticancer effects in different cancers including lung, breast, colorectal, liver, prostate, and kidney. There are challenges in the clinical use of silib...
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Article
Comparison of the Models for Correlation of Drug Solubility in Ethanol + Water Binary Mixtures
The ability of a number of common models for correlating the collected solubility data of drugs in ethanol + water mixtures (the number of data sets is 43) was tested. The selected models are classified within...
