-
Article
Open AccessSystematic assessment of long-read RNA-seq methods for transcript identification and quantification
The Long-read RNA-Seq Genome Annotation Assessment Project Consortium was formed to evaluate the effectiveness of long-read approaches for transcriptome analysis. Using different protocols and sequencing platf...
-
Article
A Causal Analysis of the Influential Criteria in Underground Mining Method Selection
The criteria affecting the choice of underground mining methods (UMMs) are interdependent and the causal relationship among them is intricate. This can cause various risks and can be a significant challenge in...
-
Article
Microplate Versus Combined Microplate-Miniplate in Fixation of Zygomaticomaxillary Complex Fractures: An In-Silico Analysis of Biomechanical Parameters
To compare the biomechanical parameters of microplates and the combined miniplate-microplate for fixing zygomaticomaxillary complex (ZMC) fractures using nonlinear finite element analysis (FEA).
-
Article
Opioid requirement and pain intensity after mandibular surgeries with dexmedetomidine administration in two ways: intraoperative infusion versus bolus injection
The purpose of this study is to compare the opioid requirement and pain intensity after surgeries of mandibular fractures with administration of dexmedetomidine by two approaches of infusion and single bolus.
-
Article
A fuzzy reinforced Jaya algorithm for solving mathematical and structural optimization problems
Jaya is a metaheuristic algorithm that uses a pair of random internal parameters to adjust its exploration and exploitation search behaviors. Such a random setting can negatively affect the search performance ...
-
Article
Correction: Solar-thermal conversion and thermal energy storage of different phase change materials
-
Article
Optimal Design of RC Bracket and Footing Systems of Precast Industrial Buildings Using Fuzzy Differential Evolution Incorporated Virtual Mutant
In a structural system, the connections (i.e., between the structural elements and the structure to the ground) play an important role in the integrity and stability of the system. So, using the certain pre-de...
-
Article
Experimental Study of True Triaxial Loading Effect on Ultrasonic Properties of Rock Salt
Because of low permeability and porosity as well as rock salt healing, salt domes are considered suitable sites for the storage of hydrocarbon, natural gas, compressed air, and nuclear waste. Applying high dev...
-
Article
Solar-thermal conversion and thermal energy storage of different phase change materials
In the present study, various phase change materials (PCMs) in combination with thermoelectric device were evaluated to storage solar energy and generate electricity. The PCMs were Rubitherm 35HC and Rubitherm...
-
Article
Open AccessL-GIREMI uncovers RNA editing sites in long-read RNA-seq
Although long-read RNA-seq is increasingly applied to characterize full-length transcripts it can also enable detection of nucleotide variants, such as genetic mutations or RNA editing sites, which is signific...
-
Article
Open AccessSignalling by senescent melanocytes hyperactivates hair growth
Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration1. Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi in h...
-
Article
Open AccessA Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
The TREM2 R47H variant is one of the strongest genetic risk factors for late-onset Alzheimer’s Disease (AD). Unfortunately, many current Trem2 R47H mouse models are associated with cryptic mRNA splicing of the mu...
-
Chapter
Improved Drosophila Food-Search Algorithm for Structural and Mechanical Optimization Problems
The metaheuristic optimization methods are non-gradient-based search techniques that wildly utilized for solving various optimization cases in the different disciplines. Drosophila food-search algorithm (DFO) ...
-
Article
Open AccessC5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease
Multiple studies have recognized the involvement of the complement cascade during Alzheimer’s disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerativ...
-
Article
Open AccessModulation of C5a–C5aR1 signaling alters the dynamics of AD progression
The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance o...
-
Article
Open AccessAuthor Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes
-
Article
The Consolidated Mathews Stability Graph for Open Stope Design
The stability graph method for open stope design is one of the most widely used approaches for predicting the stability of stopes in underground metalliferous mines. The primary purpose of this work is to prop...
-
Article
Open AccessSystematic phenoty** and characterization of the 5xFAD mouse model of Alzheimer’s disease
Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms and testing interventions and therapeutics. For disorders such as Alzheimer’s disease in which numerous models are being g...
-
Article
Open AccessMap** and modeling the genomic basis of differential RNA isoform expression at single-cell resolution with LR-Split-seq
The rise in throughput and quality of long-read sequencing should allow unambiguous identification of full-length transcript isoforms. However, its application to single-cell RNA-seq has been limited by throug...
-
Article
Open AccessTranscriptome analysis of heterogeneity in mouse model of metastatic breast cancer
Cancer metastasis is a complex process involving the spread of malignant cells from a primary tumor to distal organs. Understanding this cascade at a mechanistic level could provide critical new insights into ...
