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Novel HGPRT 293 A>G point mutation presenting as neonatal acute renal failure
We report on a rare case of hypoxanthine guanine phosphoribosyl transferase (HGPRT) deficiency that presented in the newborn period with acute renal failure (ARF). The clinical diagnosis was made on the basis ...
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Article
Pediatric nephrology patients are overweight: 20 years' experience in a single Canadian tertiary pediatric nephrology clinic
Obesity is an independent risk factor for chronic kidney disease (CKD). We compared the body composition of pediatric nephrology patients with that of the general child population over 2 decades.
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Article
Changing trends in the referral patterns of pediatric nephrology patients
This study investigates the changing referral patterns of young patients to a tertiary pediatric nephrology center with a well-defined catchment area over two consecutive 8.5-year periods. We paid special atte...
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Article
Payment for organ donation: unacceptable or a possible solution?
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Article
Hyperhomocysteinemia in children on renal replacement therapy
Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis in adult patients on dialysis or after kidney transplantation. There are few data on homocysteine (Hcy) concentrations...
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Article
The renal hemodynamic effects of Aspirin in newborn and young adult rabbits
A group of neonatal (n=10) and 12-week-old (n=12) anesthetized, ventilated New Zealand white rabbits received an acute i.v. dose (40 mg/kg body weight) of acetylsalicylic acid (ASA, Aspirin). In the neonatal ani...
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Article
The Renal Hemodynamic Effects of Ibuprofen in the Newborn Rabbit
In early childhood, nonsteroidal anti-inflammatory drugs are mainly used to either prevent or treat premature labor of the mother and patent ductus arteriosus of the newborn infant. The most frequently used pr...
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Article
Failure of the Loop Diuretic Torasemide to Improve Renal Function of Hypoxemic Vasomotor Nephropathy in the Newborn Rabbit
The use of diuretic therapy in vasomotor nephropathy is a controversial topic. It is generally agreed that diuretics in this situation enhance urinary output, reduce the degree of volume expansion, and improve...
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Article
Creatinine Reabsorption by the Newborn Rabbit Kidney
Plasma creatinine levels are elevated in the first postnatal days, and the highest plasma creatinine values are observed in the most premature infants. These high plasma creatinine levels remain "elevated" bey...
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Article
Pitfalls in measuring inulin and para-amino-hippuric acid clearances
Various carbohydrates and a variety of widely used medicines interfere with the generally used laboratory methods for determining inulin and para-aminohippuric acid (PAH). When these pitfalls are not recogniz...
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Article
Acquired glomerulocystic kidney disease following haemolytic-uraemic syndrome
Glomerulocystic kidney disease is a rare condition, usually seen in infants and young children, characterised by cystic dilatation of the glomeruli. It may be sporadic or represent the congenital expression of...
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Article
Oral pulse therapy with vitamin D3 for control of secondary hyperparathyroidism
Twelve dialysis patients received oral pulse therapy with 1-α-hydroxyvitamin D3 in a dose of 0.1 μg/kg body weight twice weekly and daily calcium carbonate (1.5–3.5 g) for a period of 8–12 months. This treatment ...
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Article
Diastolic function in children and adolescents on dialysis and after kidney transplantation: an echocardiographic assessment
Thirty-seven children and adolescents on renal replacement therapy (11 on haemodialysis, 14 on continuous ambulatory peritoneal dialysis and 12 after renal transplantation) were studied by echocardiography, ec...
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Article
Cerebral oedema in congenital nephrotic syndrome
We report an infant with congenital nephrotic syndrome who showed clinical and radiological evidence of cerebral oedema, which resolved during prolonged intravenous albumin therapy. The cerebral oedema in this...
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Article
The immune status of uraemic children/adolescents with chronic renal failure and renal replacement therapy
In adults with chronic renal failure (CRF) and/or renal replacement therapy (RRT) various immunological abnormalities have been described, but few data are available for the paediatric age group. We performed ...
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Article
Meeting of the European Working Group on Psychosocial Aspects of Children with Chronic Renal Failure
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Article
Intrarenal Distribution of Renin in the Develo** Rabbit
Summary: The purpose of this study was to evaluate the intrarenal distribution of renin in individual glomeruli during development in the rabbit. Superficial cortical and juxtamedullary glomeruli were obtained...
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Article
The Renin Angiotensin System in Newborn Dogs: Developmental Patterns and Response to Acute Saline Loading
Summary: Plasma renin (PRC) and aldosterone concentrations are known to be high during early postnatal life. Whether this is related to the low rates of renal blood flow or to sodium homeostasis remains unknow...
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Article
RESPONSE OF PUPPIES TO SALINE LOADING
The intrarenal patterns of blood flow and glomerular filtration chance rapidly in young animals, reflecting differential rates of maturation of the inner and outer cortex. The present studies were undertaken t...
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Article
RECURRENT HEMOLYTIC UREMIC SYNDROME WITH HYPOCOMPLEMENTEMIA
The hemolytic uremic syndrome (HUS) usually occurs as a single, acute episode. Recurrences with intervening periods of complete recovery have rarely been reported. Serum complement levels are stated to be norm...