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  1. Article

    Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes

    Diabetic peripheral neuropathy (DPN) is one of the major complications of diabetes, which contributes greatly to morbidity and mortality. There is currently no effective treatment for this disease. Exosomes ar...

    Baoyan Fan, Chao Li, Alexandra Szalad, Lei Wang, Wanlong Pan, Ruilan Zhang… in Diabetologia (2020)

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    Article

    MiR-34a Regulates Axonal Growth of Dorsal Root Ganglia Neurons by Targeting FOXP2 and VAT1 in Postnatal and Adult Mouse

    Hyperglycemia impairs nerve fibers of dorsal root ganglia (DRG) neurons, leading to diabetic peripheral neuropathy (DPN). However, the molecular mechanisms underlying DPN are not fully understood. Using a mous...

    Longfei Jia, Michael Chopp, Lei Wang, Xuerong Lu, Yi Zhang… in Molecular Neurobiology (2018)

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    Article

    MiR-29c/PRKCI Regulates Axonal Growth of Dorsal Root Ganglia Neurons Under Hyperglycemia

    Diabetes initially induces distal axonal damage of peripheral nerves, but molecular mechanisms that mediate axonal injury are not fully understood. MircoRNAs (miRNAs) regulate axonal growth. We found that diab...

    Longfei Jia, Lei Wang, Michael Chopp, Chao Li, Yi Zhang… in Molecular Neurobiology (2018)

  4. Article

    Open Access

    Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia

    Expression of the Sp1 transcription factor is induced by hypoxia, and the ADAM17 promoter contains predicted Sp1 binding sites. ADAM17 contributes to hypoxic-induce invasiveness of glioma. In this study, we in...

    Alexandra Szalad, Mark Katakowski… in Journal of Experimental & Clinical Cancer … (2009)

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