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    Article

    Überdosierung von direkten oralen Antikoagulanzien

    Direkte orale Antikoagulanzien (DOAK) werden zunehmend zur Prophylaxe und Therapie thromboembolischer Ereignisse eingesetzt. Eine fehldosierte DOAK-Therapie ist mit einer Übersterblichkeit verbunden.

    Marie Anne-Catherine Neumann, Noëlle Sieg in Medizinische Klinik - Intensivmedizin und … (2024)

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    Übergaben auf der Intensivstation

    Eine effektive Übergabe auf der Intensivstation ist ein zentrales Element einer sicheren Patient*innenversorgung.

    Eyleen Reifarth M.A, Jan-Hendrik Naendrup in Medizinische Klinik - Intensivmedizin und … (2024)

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    Open Access

    Teamspezifische Auswirkungen der Corona-Pandemie auf Mitarbeiter:innen der Internistischen Intensivmedizin eines Krankenhauses der Maximalversorgung

    Die anhaltende Belastung der Mitarbeiter im Gesundheitsdienst während der COVID-19-Pandemie ist erheblich und stellt die Mitarbeiter vor große emotionale und psychologische Herausforderungen. In einer teaminte...

    Jochen Wolff, Jürgen Becker in Medizinische Klinik - Intensivmedizin und … (2023)

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    Open Access

    Characteristics and outcomes of patients undergoing high-dose chemotherapy and autologous stem cell transplantation admitted to the intensive care unit: a single-center retrospective analysis

    High-dose chemotherapy and autologous stem cell transplantation (ASCT) can be associated with adverse events necessitating treatment on the intensive care unit (ICU). Data focusing on patients admitted to the ...

    Jorge Garcia Borrega, Boris Böll, Matthias Kochanek in Annals of Hematology (2023)

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    Open Access

    Veno-venous extracorporeal membrane oxygenation (vv-ECMO) for severe respiratory failure in adult cancer patients: a retrospective multicenter analysis

    The question of whether cancer patients with severe respiratory failure benefit from veno-venous extracorporeal membrane oxygenation (vv-ECMO) remains unanswered. We, therefore, analyzed clinical characteristi...

    Matthias Kochanek, Jan Kochanek, Boris Böll in Intensive Care Medicine (2022)

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    Open Access

    Allogeneic stem cell transplant recipients admitted to the intensive care unit during the peri-transplant period have unfavorable outcomes—results of a retrospective analysis from a German university hospital

    The prognosis of allogeneic stem cell transplant recipients admitted to the intensive care unit (ICU) has improved over the last decades. However, data focusing on patients treated in the ICU during the peri-t...

    Jorge Garcia Borrega, Jan-Michel Heger, Philipp Koehler in Annals of Hematology (2022)

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    Open Access

    Prognostic accuracy of SOFA, qSOFA and SIRS criteria in hematological cancer patients: a retrospective multicenter study

    With Sepsis-3, the increase in sequential organ failure assessment (SOFA) as a clinical score for the identification of patients with sepsis and quickSOFA (qSOFA) for the identification of patients at risk of ...

    Lucie Probst, Enrico Schalk, Tobias Liebregts, Vanja Zeremski in Journal of Intensive Care (2019)

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    ‘Lost in Nasal Space’: Staphylococcus aureus sepsis associated with Nasal Handkerchief Packing

    Staphylococcus aureus frequently causes infections in outpatient and hospital settings and can present as a highly variable entity. Typical manifestations are endocarditis, osteoarticular infections or infection ...

    Philipp Koehler, Norma Jung, Matthias Kochanek, Philipp Lohneis in Infection (2019)

  9. Article

    Open Access

    Cytokine release syndrome

    During the last decade the field of cancer immunotherapy has witnessed impressive progress. Highly effective immunotherapies such as immune checkpoint inhibition, and T-cell engaging therapies like bispecific ...

    Alexander Shimabukuro-Vornhagen, Philipp Gödel in Journal for ImmunoTherapy of Cancer (2018)

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    Understanding cytokine release syndrome

    Philipp Gödel, Alexander Shimabukuro-Vornhagen in Intensive Care Medicine (2018)

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    Article

    CD4+ T cell counts reflect the immunosuppressive state of CD4 helper cells in patients after allogeneic stem cell transplantation

    The recovery of the host immune system after allogeneic hematopoietic stem cell transplantation is pivotal to prevent infections, relapse, and secondary malignancies. In particular, numerical CD4+ T cells reco...

    Udo Holtick, Lukas P. Frenzel, Alexander Shimabukuro-Vornhagen in Annals of Hematology (2015)

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    Article

    Intermediate intensity conditioning regimen containing FLAMSA, treosulfan, cyclophosphamide, and ATG for allogeneic stem cell transplantation in elderly patients with relapsed or high-risk acute myeloid leukemia

    Lower dosage of total body irradiation (TBI) and chemotherapy in reduced-intensity conditioning (RIC) regimens prior to allogeneic stem cell transplantation have reduced the toxicity of the conditioning and no...

    Jens Marcus Chemnitz, Marie von Lilienfeld-Toal, Udo Holtick in Annals of Hematology (2012)

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    Open Access

    Improvement of platelet dysfunction in chronic myelogenous leukemia following treatment with imatinib: a case report

    In patients with chronic myeloid leukemia, tyrosine kinase inhibitors suppress the BCR-ABL + clone and often induce complete molecular remissions. Megakaryocytes in such patients have been shown to be derived fro...

    Alexander Shimabukuro-Vornhagen, Achim Rothe in Journal of Medical Case Reports (2011)