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Article
Überdosierung von direkten oralen Antikoagulanzien
Direkte orale Antikoagulanzien (DOAK) werden zunehmend zur Prophylaxe und Therapie thromboembolischer Ereignisse eingesetzt. Eine fehldosierte DOAK-Therapie ist mit einer Übersterblichkeit verbunden.
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Article
Übergaben auf der Intensivstation
Eine effektive Übergabe auf der Intensivstation ist ein zentrales Element einer sicheren Patient*innenversorgung.
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Article
Open AccessTeamspezifische Auswirkungen der Corona-Pandemie auf Mitarbeiter:innen der Internistischen Intensivmedizin eines Krankenhauses der Maximalversorgung
Die anhaltende Belastung der Mitarbeiter im Gesundheitsdienst während der COVID-19-Pandemie ist erheblich und stellt die Mitarbeiter vor große emotionale und psychologische Herausforderungen. In einer teaminte...
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Article
Open AccessCharacteristics and outcomes of patients undergoing high-dose chemotherapy and autologous stem cell transplantation admitted to the intensive care unit: a single-center retrospective analysis
High-dose chemotherapy and autologous stem cell transplantation (ASCT) can be associated with adverse events necessitating treatment on the intensive care unit (ICU). Data focusing on patients admitted to the ...
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Article
Open AccessVeno-venous extracorporeal membrane oxygenation (vv-ECMO) for severe respiratory failure in adult cancer patients: a retrospective multicenter analysis
The question of whether cancer patients with severe respiratory failure benefit from veno-venous extracorporeal membrane oxygenation (vv-ECMO) remains unanswered. We, therefore, analyzed clinical characteristi...
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Article
Open AccessAllogeneic stem cell transplant recipients admitted to the intensive care unit during the peri-transplant period have unfavorable outcomes—results of a retrospective analysis from a German university hospital
The prognosis of allogeneic stem cell transplant recipients admitted to the intensive care unit (ICU) has improved over the last decades. However, data focusing on patients treated in the ICU during the peri-t...
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Article
Open AccessPrognostic accuracy of SOFA, qSOFA and SIRS criteria in hematological cancer patients: a retrospective multicenter study
With Sepsis-3, the increase in sequential organ failure assessment (SOFA) as a clinical score for the identification of patients with sepsis and quickSOFA (qSOFA) for the identification of patients at risk of ...
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Article
‘Lost in Nasal Space’: Staphylococcus aureus sepsis associated with Nasal Handkerchief Packing
Staphylococcus aureus frequently causes infections in outpatient and hospital settings and can present as a highly variable entity. Typical manifestations are endocarditis, osteoarticular infections or infection ...
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Article
Open AccessCytokine release syndrome
During the last decade the field of cancer immunotherapy has witnessed impressive progress. Highly effective immunotherapies such as immune checkpoint inhibition, and T-cell engaging therapies like bispecific ...
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Article
Understanding cytokine release syndrome
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Article
CD4+ T cell counts reflect the immunosuppressive state of CD4 helper cells in patients after allogeneic stem cell transplantation
The recovery of the host immune system after allogeneic hematopoietic stem cell transplantation is pivotal to prevent infections, relapse, and secondary malignancies. In particular, numerical CD4+ T cells reco...
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Article
Open AccessThe immunosuppressive factors IL-10, TGF-β, and VEGF do not affect the antigen-presenting function of CD40-activated B cells
Progress in recent years strengthened the concept of cellular tumor vaccinations. However, a crucial barrier to successful cancer immunotherapy is tumor-mediated immunosuppression. Tumor-derived soluble factor...
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Article
Intermediate intensity conditioning regimen containing FLAMSA, treosulfan, cyclophosphamide, and ATG for allogeneic stem cell transplantation in elderly patients with relapsed or high-risk acute myeloid leukemia
Lower dosage of total body irradiation (TBI) and chemotherapy in reduced-intensity conditioning (RIC) regimens prior to allogeneic stem cell transplantation have reduced the toxicity of the conditioning and no...
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Article
Open AccessImprovement of platelet dysfunction in chronic myelogenous leukemia following treatment with imatinib: a case report
In patients with chronic myeloid leukemia, tyrosine kinase inhibitors suppress the BCR-ABL + clone and often induce complete molecular remissions. Megakaryocytes in such patients have been shown to be derived fro...