11 Result(s)
within
Alexander Schramm
Oncology
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Article
Open AccessBRAF inhibitors in BRAF V600E-mutated ameloblastoma: systematic review of rare cases in the literature
Ameloblastoma in 66% of the cases harbor a somatic mutation of the “mitogen-activated protein kinase” signaling pathway (BRAF V600E). In V600E mutations, BRAF is in the permanent “on” state and relays the grow...
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Article
Open AccessFunctional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis
Lung cancer mortality largely results from metastasis. Despite curative surgery many patients with early-stage non-small cell lung cancer ultimately succumb to metastatic relapse. Current risk reduction strate...
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Article
Targeting of MYCN by means of DNA vaccination is effective against neuroblastoma in mice
The MYCN oncogene is a strong genetic marker associated with poor prognosis in neuroblastoma (NB). Therefore, MYCN gene amplification and subsequent overexpression provide a possible target for new treatment appr...
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Article
Open AccessThe BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. While current treatment regimens achieve almost 80% overall survival, long-term side effects of chemotherapeutic agents can be severe. Th...
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Article
Open AccessCADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23
Recurrent loss of part of the long arm of chromosome 11 is a well established hallmark of a subtype of aggressive neuroblastomas. Despite intensive map** efforts to localize the culprit 11q tumour suppressor...
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Article
Arteriovenous malformation of the mandible: a life-threatening situation
Arteriovenous malformation (AVM) of the mandible is not only a rare entity, but also one that can be potentially life threatening due to massive haemorrhage. The authors describe three cases of children with A...
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Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling
Neuroblastoma is a common childhood tumor comprising cases with rapid disease progression as well as spontaneous regression. Although numerous prognostic factors have been identified, risk evaluation in indivi...
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Article
Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma
The paediatric eye tumour retinoblastoma is initiated by inactivation of RB1, a tumour suppressor on chromosome 13q. In addition to RB1 loss, many retinoblastomas show other genetic alterations including gains...
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Article
High activin A-expression in human neuroblastoma: suppression of malignant potential and correlation with favourable clinical outcome
Amplification of the MYCN oncogene contributes to the malignant progression of human neuroblastomas, but the mechanisms have remained unclear. We have previously demonstrated that N-Myc facilitates angiogenesis b...
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Article
Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas
Expression of neurotrophin receptors of the tyrosine kinase receptor (Trk) family is an important prognostic factor in solid tumors including neuroblastoma. High expression of TrkA (NTRK1) is associated with a...
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Article
The Phox2B homeobox gene is mutated in sporadic neuroblastomas
Neuroblastomas are embryonal tumours of the sympatho-adrenal lineage with a clinical course ranging from spontaneous regression to fatal progression. The Phox2B homeobox transcription factor functions in the d...
