-
Article
Open AccessMetabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse model...
-
Article
Open AccessOncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis
Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct mutational profile, characterized by oncogenic BRAF mutations and aberrations in mismatch repair and TGFβ signalling. Here, we de...
-
Article
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration
Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to regeneration by restoring both hepatocytes and cholangiocytes. We recently showed that ductal cells clonally expand a...
-
Article
Open AccessBasal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal
A central question in stem cell biology is the relationship between stem cells and their niche. Although previous reports have uncovered how signaling molecules released by niche cells support stem cell functi...
-
Article
Open AccessParacrine cellular senescence exacerbates biliary injury and impairs regeneration
Cellular senescence is a mechanism that provides an irreversible barrier to cell cycle progression to prevent undesired proliferation. However, under pathological circumstances, senescence can adversely affect...
-
Article
Correction: Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration
Nature 547, 350–354 (2017); doi:10.1038/nature23015 In Extended Data Fig. 10b of this Letter, the axes of the single-cell gating (middle panel) FACS plots were mislabelled. Single cells were gated using forwar...
-
Article
Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration
Two independent systems impairing hepatocyte proliferation during liver injury cause physiologically significant levels of functional hepatocyte regeneration from biliary cells.
