11 Result(s)
within
Alexander Brobeil
English
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Article
Open AccessDeep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology
In the spectrum of colorectal tumors, microsatellite-stable (MSS) tumors with DNA polymerase ε (POLE) mutations exhibit a hypermutated profile, holding the potential to respond to immunotherapy similarly to their...
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Open AccessMultimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities
The redirection of T cells has emerged as an attractive therapeutic principle in B cell non-Hodgkin lymphoma (B-NHL). However, a detailed characterization of lymphoma-infiltrating T cells across B-NHL entities...
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Open AccessAuthor Correction: Regression-based Deep-Learning predicts molecular biomarkers from pathology slides
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Open AccessRegression-based Deep-Learning predicts molecular biomarkers from pathology slides
Deep Learning (DL) can predict biomarkers from cancer histopathology. Several clinically approved applications use this technology. Most approaches, however, predict categorical labels, whereas biomarkers are ...
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Open AccessHigh-throughput electron tomography identifies centriole over-elongation as an early event in plasma cell disorders
Plasma cell disorders are clonal outgrowths of pre-malignant or malignant plasma cells, characterized by extensive chromosomal aberrations. Centrosome abnormalities are a major driver of chromosomal instabilit...
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Open AccessFunctionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma
Cutaneous squamous cell carcinoma (cSCC) is a serious public health problem due to its high incidence and metastatic potential. It may progress from actinic keratosis (AK), a precancerous lesion, or the in sit...
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Open AccessResolving the spatial architecture of myeloma and its microenvironment at the single-cell level
In multiple myeloma spatial differences in the subclonal architecture, molecular signatures and composition of the microenvironment remain poorly characterized. To address this shortcoming, we perform multi-re...
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Open AccessStandardizing lymphangiography and lymphatic interventions: a preclinical in vivo approach with detailed procedural steps
To present a preclinical in vivo approach for standardization and training of lymphangiography and lymphatic interventions using a pictorial review.
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Open AccessSpatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis
Intraductal papillary neoplasms (IPN) and biliary epithelial neoplasia (BilIN) are well‐defined precursor lesions of biliary tract carcinoma (BTC). The aim of this study was to provide a comprehensive characte...
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Article
Response to ‘Aberrant expression of TdT in seminomatous germ cell neoplasia’
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Open AccessEffectiveness of EGFR/HER2-targeted drugs is influenced by the downstream interaction shifts of PTPIP51 in HER2-amplified breast cancer cells
Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20–30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled ...
