17 Result(s)
within
Alexander Brobeil
English
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Article
Open AccessDeep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology
In the spectrum of colorectal tumors, microsatellite-stable (MSS) tumors with DNA polymerase ε (POLE) mutations exhibit a hypermutated profile, holding the potential to respond to immunotherapy similarly to their...
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Open AccessMultimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities
The redirection of T cells has emerged as an attractive therapeutic principle in B cell non-Hodgkin lymphoma (B-NHL). However, a detailed characterization of lymphoma-infiltrating T cells across B-NHL entities...
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Open AccessAuthor Correction: Regression-based Deep-Learning predicts molecular biomarkers from pathology slides
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Open AccessRegression-based Deep-Learning predicts molecular biomarkers from pathology slides
Deep Learning (DL) can predict biomarkers from cancer histopathology. Several clinically approved applications use this technology. Most approaches, however, predict categorical labels, whereas biomarkers are ...
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Open AccessHigh-throughput electron tomography identifies centriole over-elongation as an early event in plasma cell disorders
Plasma cell disorders are clonal outgrowths of pre-malignant or malignant plasma cells, characterized by extensive chromosomal aberrations. Centrosome abnormalities are a major driver of chromosomal instabilit...
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Open AccessFunctionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma
Cutaneous squamous cell carcinoma (cSCC) is a serious public health problem due to its high incidence and metastatic potential. It may progress from actinic keratosis (AK), a precancerous lesion, or the in sit...
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Open AccessResolving the spatial architecture of myeloma and its microenvironment at the single-cell level
In multiple myeloma spatial differences in the subclonal architecture, molecular signatures and composition of the microenvironment remain poorly characterized. To address this shortcoming, we perform multi-re...
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Open AccessStandardizing lymphangiography and lymphatic interventions: a preclinical in vivo approach with detailed procedural steps
To present a preclinical in vivo approach for standardization and training of lymphangiography and lymphatic interventions using a pictorial review.
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Open AccessSpatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis
Intraductal papillary neoplasms (IPN) and biliary epithelial neoplasia (BilIN) are well‐defined precursor lesions of biliary tract carcinoma (BTC). The aim of this study was to provide a comprehensive characte...
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Genoty** circulating tumor DNA of pediatric Hodgkin lymphoma
We used hybrid capture-targeted next-generation sequencing of circulating cell-free DNA (ccfDNA) of pediatric Hodgkin lymphoma (PHL) patients to determine pathogenic mechanisms and assess the clinical utility ...
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Response to ‘Aberrant expression of TdT in seminomatous germ cell neoplasia’
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Open AccessEffectiveness of EGFR/HER2-targeted drugs is influenced by the downstream interaction shifts of PTPIP51 in HER2-amplified breast cancer cells
Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20–30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled ...
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Expression of terminal deoxynucleotidyl transferase (TdT) in classical seminoma: a potential diagnostic pitfall
Seminomas are the most frequent testicular tumors and in spite of specific markers some histological subtypes can be diagnostically challenging due to the potential overlap of morphologic features and a varian...
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The role of high-risk human papillomavirus infections in laryngeal squamous cell carcinoma
The contribution of human papillomavirus (HPV) to the development and clinical outcome of oropharyngeal cancers has been well documented. The association of HPV in laryngeal squamous cell carcinoma (LSCC) has ...
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Orchestrating cellular signaling pathways—the cellular “conductor” protein tyrosine phosphatase interacting protein 51 (PTPIP51)
The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is thought to regulate crucial cellular functions such as mitosis, apoptosis, migration, differentiation and communication between organelles a...
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PTPIP51 in Protein Interactions: Regulation and In Situ Interacting Partners
This study investigated the regulation of 14-3-3β binding to PTPIP51 by the tyrosine phosphorylation status of PTPIP51. The tyrosine 176 residue is phosphorylated by c-Src. Up to now, nothing is known about th...
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Protein tyrosine phosphatase interacting protein 51—a jack-of-all-trades protein
Protein tyrosine phosphatase interacting protein 51 (PTPIP51) interacts both in vitro and in vivo with PTP1B, a protein tyrosine phosphatase involved in cellular regulation. PTPIP51 is known to be expressed in...
