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Article
Open AccessThe landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly recognized in adults. Their potential heterogeneity ...
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Article
Application of an advanced noise reduction algorithm for imaging of hands in rheumatic diseases: evaluation of image quality compared to standard-dose images
X-ray is the fundamental imaging technique in both diagnosis and follow-up of rheumatic diseases. As patients often require sequential X-rays over many years, dose reduction is of great importance. New advance...
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Article
Open AccessMannosylerythritollipide — mikrobielle Biotenside aus dem Bioreaktor
Mannosylerythritol lipids (MEL) are microbial biosurfactants belonging to the class of glycolipids. They can be produced biotechnologically by smut fungi and have the potential to replace current chemical surf...
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Article
Open AccessInfluence of reduction accuracy in lateral tibial plateau fractures on intra-articular friction – a biomechanical study
Lateral tibial split fractures (LTSF) usually require surgical therapy with screw or plate osteosynthesis. Excellent anatomical reduction of the fracture is thereby essential to avoid post-traumatic osteoarthr...
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Article
Influence of microorganism and plant oils on the structure of mannosylerythritol lipid (MEL) biosurfactants revealed by a novel thin layer chromatography mass spectrometry method
Mannosylerythritol lipids (MEL) are microbial glycolipid biosurfactants with great potential for application in cosmetics and household detergents. In current biotechnological processes, they are produced by b...
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Article
Open AccessOverexpression of UHRF1 promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma
Hepatoblastoma (HB) is the most common liver tumor of childhood and occurs predominantly within the first 3 years of life. In accordance to its early manifestation, HB has been described to display an extremel...
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Chapter and Conference Paper
Paradigms of Shear in Structural Concrete - Review and Experimental Verification
Despite hundreds of theoretical and experimental investigations carried out to date, the shear behaviour of structural concrete girders and slabs with little or no transverse reinforcement remains a controvers...
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Article
How to understand the complexity of product quality and the challenges in differentiating between organically and conventionally grown products—exemplified by fresh and heat-processed carrots (Daucus carota L.)
Quality traits are highly focused upon in the marketing of organic food products. There is a need to define and measure quality as consumers seem to have preconceived notions about the superior health value an...
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Chapter
Opening Up Data Analysis for Medical Health Services: Data Integration and Analysis in Cancer Registries with CARESS
Dealing with cancer is one of the big challenges of the German healthcare system. Todays efforts regarding the analysis of cancer data incorporate detection of spatial clusters as well as complex health servic...
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Article
Aufbau eines neuronalen Netzes zur Schwachstellenaggregation
Eine automatisierte Sicherheitsbewertung von Systemen würde für eine ständige Aktualität der Risikobewertung führen, könnte punktuelle Audits ersetzen und würde für eine bessere Vergleichbarkeit von Bewertunge...
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Article
Open AccessMR-guided high-focused ultrasound for renal sympathetic denervation—a feasibility study in pigs
Renal sympathetic denervation has recently gained clinical relevance for the treatment of therapy-resistant hypertension. Denervation is currently mainly performed using catheter-based transarterial radiofrequ...
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Chapter
Interventional Oncology
Percutaneous thermal ablation therapy represents a local tumor treatment. Hyperthermal ablation procedures eradicate tumor tissue with heat in a circumscribed area. Applied techniques are radiofrequency (RF) a...
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Article
Impact of Ga-68 DOTATOC PET/CT on the diagnosis and treatment of patients with multiple endocrine neoplasia
To evaluate the impact of Ga-68 DOTATOC PET/CT on diagnosis and therapeutic management of patients with multiple endocrine neoplasia (MEN).
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Chapter and Conference Paper
Unsaturated Hydraulic Conductivity of a Silty Sand with the Instantaneous Profile Method
The unsaturated hydraulic conductivity of a silty sand at different initial void ratios is measured using the instantaneous profile method. The variation of the suction and volumetric water content is recorded...
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Chapter
Interventional Oncology
Percutaneous thermal ablation therapy represents a local tumor treatment. Hyperthermal ablation procedures eradicate tumor tissue with heat in a circumscribed area. Applied techniques are radiofrequency (RF) a...
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Article
Sonographically guided venous puncture and fluoroscopically guided placement of tunneled, large-bore central venous catheters for bone marrow transplantation—high success rates and low complication rates
Traditionally, large lumen, tunneled central venous catheters have been implanted by surgeons. We used a technique of sonographically guided jugular venous puncture and fluoroscopically guided catheter placeme...
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Article
Value of apoptin’s 40-amino-acid C-terminal fragment for the differentiation between human tumor and non-tumor cells
Apoptin, a protein of the chicken anemia virus (CAV), consists of 121 amino acids (aa) and represents a novel, potentially tumor-specific therapeutic and diagnostic agent. The C-terminal part of Apoptin (aa 81...
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Article
Effects of diclofenac on periosteal callus maturation in osteotomy healing in an animal model
Potential adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on bone metabolism and fracture healing are contradictive to their wide application in post-traumatic treatment. Our objective was to ...
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Article
The immunologically active site of prothymosin α is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients
Prothymosin α (proTα) is a 109 amino acid long polypeptide presenting distinct immunoenhancing activity in vitro and in vivo. Recent reports suggest that in apoptotic cells, proTα is cleaved by caspases at its ca...
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Article
CT-gesteuerte Brachytherapie
Analyse der Sicherheit und Effektivität CT-gesteuerter Brachytherapie zur Ablation von Lebermalignomen.
