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  1. No Access

    Article

    Structure and assembly of a bacterial gasdermin pore

    In response to pathogen infection, gasdermin (GSDM) proteins form membrane pores that induce a host cell death process called pyroptosis1–3. Studies of human and mouse GSDM pores have revealed the functions and a...

    Alex G. Johnson, Megan L. Mayer, Stefan L. Schaefer, Nora K. McNamara-Bordewick… in Nature (2024)

  2. Article

    Open Access

    Structural basis of Gabija anti-phage defence and viral immune evasion

    Bacteria encode hundreds of diverse defence systems that protect them from viral infection and inhibit phage propagation1–5. Gabija is one of the most prevalent anti-phage defence systems, occurring in more than ...

    Sadie P. Antine, Alex G. Johnson, Sarah E. Mooney, Azita Leavitt, Megan L. Mayer… in Nature (2024)

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    Article

    eIF5B gates the transition from translation initiation to elongation

    Translation initiation determines both the quantity and identity of the protein that is encoded in an mRNA by establishing the reading frame for protein synthesis. In eukaryotic cells, numerous translation ini...

    **fan Wang, Alex G. Johnson, Christopher P. Lapointe, Junhong Choi… in Nature (2019)