4 Result(s)
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Article
Open AccessAPR-246 as a radiosensitization strategy for mutant p53 cancers treated with alpha-particles-based radiotherapy
Radiation therapy (RT) remains a common treatment for cancer patients worldwide, despite the development of targeted biological compounds and immunotherapeutic drugs. The challenge in RT lies in delivering a l...
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Article
Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cells
The ZAP70 protein tyrosine kinase (PTK) couples stimulated T cell antigen receptors (TCRs) to their downstream signal transduction pathways and is sine qua non for T cell activation and differentiation. TCR engag...
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Article
Open AccessPICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter
Protein kinase C (PKC)-interacting cousin of thioredoxin (PICOT; also termed glutaredoxin 3 (Grx3; Glrx3)) is a ubiquitous protein that can interact with the embryonic ectoderm development (EED) protein via ea...
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Article
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1
Receptor oligomerization is vital for activating intracellular signaling, in part by initiating events that recruit effector and adaptor proteins to sites of active signaling. Whether these distal molecules th...
