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Open AccessDonor’s age influences outcome in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide - a single center experience
Haploidentical stem cell transplantation (haplo-SCT) using post-transplantation cyclophosphamide (post-Cy) is considered a reasonable therapeutic option for patients who lack matched donor or who urgently need...
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Article
Open AccessIdentification of novel genetic loci for risk of multiple myeloma by functional annotation
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Open AccessTelomere length and hTERT genetic variants as potential prognostic markers in multiple myeloma
Telomere dysfunction is a notable event observed in many cancers contributing to their genomic instability. A major factor controlling telomere stability is the human telomerase reverse transcriptase catalytic...
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Article
Open AccessValidation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia: a CRuCIAL study
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Open AccessTERT genetic variability and telomere length as factors affecting survival and risk in acute myeloid leukaemia
Acute myeloid leukaemia (AML) is a neoplasm of immature myeloid cells characterized by various cytogenetic alterations. The present study showed that in addition to the FLT3-ITD and NPM1 mutation status, telomere...
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Article
Open AccessGenetically determined telomere length and multiple myeloma risk and outcome
Telomeres are involved in processes like cellular growth, chromosomal stability, and proper segregation to daughter cells. Telomere length measured in leukocytes (LTL) has been investigated in different cancer...
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Article
Open AccessGenetic polymorphisms associated with telomere length and risk of develo** myeloproliferative neoplasms
Telomere length measured in leukocyte (LTL) has been found to be associated with the risk of develo** several cancer types, including myeloproliferative neoplasms (MPNs). LTL is genetically determined by, at...
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Article
Open AccessPrevalence and clinical presentation of lymphoproliferative disorder in patients with primary Sjögren’s syndrome
Lymphomas are one of the serious complications of the primary Sjörgen’s Syndrome (pSS). The aim of the study was to evaluate the frequency of lymphoma in pSS. The singe-center retrospective study included 198 ...
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Article
Open AccessExome sequencing identifies germline variants in DIS3 in familial multiple myeloma
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Open AccessGenetic variation of the gene coding for microRNA-204 (miR-204) is a risk factor in acute myeloid leukaemia
MicroRNAs (miRNAs or miRs) are small molecules known to be involved in post-transcriptional gene expression. Many of them have been shown to influence risk for various diseases. Recent studies suggest that low...
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Article
Open AccessAzacitidine improves clinical outcomes in older patients with acute myeloid leukaemia with myelodysplasia-related changes compared with conventional care regimens
Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to hav...
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Article
Open AccessCereblon and IRF4 Variants Affect Risk and Response to Treatment in Multiple Myeloma
Multiple myeloma (MM) is a plasma-cell malignancy derived from an early precursor of the B-cell lineage characterised by bone-marrow infiltration, lytic bone lesions, and the presence of a monoclonal protein i...
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Open AccessThe Expression of Toll-Like Receptors in Patients with B-Cell Chronic Lymphocytic Leukemia
B-cell chronic lymphocytic leukemia (B-CLL) presents with progressive accumulation of monoclonal B cells in the peripheral blood, bone marrow and lymphoid organs. B-CLL is characterized by heterogeneous clinic...
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Open AccessPolish experience of lenalidomide in the treatment of lower risk myelodysplastic syndrome with isolated del(5q)
Lenalidomide has been approved for the treatment of lower-risk myelodysplastic syndrome (MDS) with 5q deletion (del(5q)). We present for the first time a retrospective analysis of low-risk MDS with isolated de...
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Open AccessLow expression of microRNA-204 (miR-204) is associated with poor clinical outcome of acute myeloid leukemia (AML) patients
Acute myeloid leukemia (AML) is a heterogeneous neoplasm of the bone marrow with poor prognosis. In clinical practice new prognostic factors are still needed. MicroRNAs (miRs), small endogenous noncoding RNAs,...
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Open AccessThe expression of Toll-like receptors and development of severe sepsis in patients with acute myeloid leukemias after induction chemotherapy
Toll-like receptors play an important role in the host defense against microorganisms. Sepsis remains a common cause of mortality in patients with acute myeloid leukemia (AML) treated with intensive induction ...
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Open AccessHigh CD74 expression correlates with ZAP70 expression in B cell chronic lymphocytic leukemia patients
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. It is characterized by heterogeneous clinical course of the disease and new prognostic factors are still needed. C...
