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Article
Open AccessVaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota
The gut microbiota is emerging as a crucial factor modulating vaccine responses; however, few studies have investigated if vaccines, in turn, can alter the microbiota and to what extent such changes may improv...
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Article
Open AccessPitting of malaria parasites in microfluidic devices mimicking spleen interendothelial slits
The spleen is a hematopoietic organ that participates in cellular and humoral immunity. It also serves as a quality control mechanism for removing senescent and/or poorly deformable red blood cells (RBCs) from...
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Article
Open AccessCryptic Plasmodium chronic infections: was Maurizio Ascoli right?
Cryptic Plasmodium niches outside the liver possibly represent a major source of hypnozoite-unrelated recrudescences in malaria. Maurizio Ascoli, an Italian physician and scientist, suggested that infection was m...
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Article
Open AccessSudden spleen rupture in a Plasmodium vivax-infected patient undergoing malaria treatment
Splenomegaly is one of the most common features of malaria. However, spontaneous splenic rupture, although unusual, represents a severe complication often leading to death. It is mostly seen in acute infection...
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Article
Open AccessReticulocyte-prone malaria parasites predominantly invade CD71hi immature cells: implications for the development of an in vitro culture for Plasmodium vivax
The lack of a continuous in vitro culture system for blood stages of malarial parasites with a unique tropism for reticulocytes, such as Plasmodium vivax and the Plasmodium yoelii 17X reticulocyte-prone strain, h...