-
Article
Open AccessRelationship between paediatric CT scans and subsequent risk of leukaemia and brain tumours: assessment of the impact of underlying conditions
We previously reported evidence of a dose–response relationship between ionising-radiation exposure from paediatric computed tomography (CT) scans and the risk of leukaemia and brain tumours in a large UK coho...
-
Article
Open AccessSmall-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology
The aetiology of bone cancers is poorly understood. This study examined geographical patterning in incidence of primary bone cancers diagnosed in 0–49 year olds in Great Britain during 1980–2005 to provide inf...
-
Article
Open AccessSocio-economic variation in CT scanning in Northern England, 1990-2002
Socio-economic status is known to influence health throughout life. In childhood, studies have shown increased injury rates in more deprived settings. Socio-economic status may therefore be related to rates of...
-
Article
CT scans in young people in Northern England: trends and patterns 1993–2002
Although CT can be greatly beneficial, its relatively high radiation doses have caused public health concerns.
-
Article
Height at diagnosis and birth-weight as risk factors for osteosarcoma
Osteosarcoma typically occurs during puberty. Studies of the association between height and/or birth-weight and osteosarcoma are conflicting. Therefore, we conducted a large pooled analysis of height and birth...
-
Chapter
Osteosarcoma: The European Osteosarcoma Intergroup (EOI) Perspective
In the late 1970s, there was confusion regarding the best management for osteosarcoma. The benefit of chemotherapy had not been established and which chemotherapy could be used was even more uncertain. The Eur...
-
Article
Open AccessSex-specific incidence and temporal trends in solid tumours in young people from Northern England, 1968–2005
This study examined sex-specific patterns and temporal trends in the incidence of solid tumours in the Northern Region of England from 1968 to 2005. This updates earlier analyses from the region where sex was ...
-
Article
Prohibitive toxicity of a dose-intense regime for metastatic neuroblastoma containing ifosfamide, doxorubicin and cisplatin
Three patients with stage 4 neuroblastoma were treated with a schedule comprising alternating modules of myelosuppressive (ifosfamide, etoposide, doxorubicin) and less myelosuppressive (vincristine, cisplatin)...
-
Article
Assessment of chemotherapy-associated nephrotoxicity in children with cancer
Assessment of the toxicity caused by chemotherapy in children with cancer has become more important as the number of long-term survivors has continued to increase. It is vital to monitor both acute life-threat...
-
Article
Toxicity of high-dose ifosfamide in children
Ifosfamide has been shown to be an active agent in the treatment of several childhood cancers. However, the optimal dose and method of administration remains to be established. The dose/response relationship o...
-
Chapter
Accidental injury and death in children
Accidents are by far and away the commonest cause of death in childhood and are an equally important reason for the admission of children to hospital. Although accident rates have fallen slowly throughout this...
-
Article
Pharmacokinetics of oral and intramuscular methotrexate in children with acute lymphoblastic leukaemia
Repeated methotrexate absorption studies were performed under standard conditions in 127 children receiving either oral or intramuscular methotrexate for acute lymphoblastic leukaemia. There was marked variabi...
