Page
%P
-
Chapter
An Introduction to Peptidases and the Merops Database
-
Article
Open AccessA comparison of Pfam and MEROPS: Two databases, one comprehensive, and one specialised.
We wished to compare two databases based on sequence similarity: one that aims to be comprehensive in its coverage of known sequences, and one that specialises in a relatively small subset of known sequences. ...
-
Chapter
Peptidases: a view of classification and nomenclature
It is beyond question that the results of research on proteolytic enzymes, or peptidases, are already benefiting mankind in many ways, and there is no doubt that research in this area has the potential to cont...
-
Article
An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation
Foreign protein antigens must be broken down within endosomes or lysosomes to generate suitable peptides that will form complexes with class II major histocompatibility complex molecules for presentation to T ...
-
Article
Families and clans of cysteine peptidases
The known cysteine peptidases have been classified into 35 sequence families. We argue that these have arisen from at least five separate evolutionary origins, each of which is represented by a set of one or m...
-
Article
The possible role of neutrophil proteinases in damage to articular cartilage
The proteolytic degradation of articular cartilage that is seen in the arthritides affects both of the major structural components of the tissue, proteoglycan and collagen. Neutrophil leucocytes are abundant i...
-
Article
Evolution of proteins of the cystatin superfamily
We have examined the amino acid sequences of a number of proteins that have been suggested to be related to chicken cystatin, a protein from chicken egg white that inhibits cysteine proteinases. On the basis o...
-
Article
The possible role of neutrophil proteinases in damage to articular cartilage
The proteolytic degradation of articular cartilage that is seen in the arthritides affects both of the major structural components of the tissue, proteoglycan and collagen. Neutrophil leucocytes are abundant i...
-
Book
-
Chapter
Human Cathepsin D
Our interest in cathepsin D arose from the observation that agents such as vitamin A alcohol and complement-sufficient antiserum, which caused a dramatic catabolism of cartilage matrix in a culture system, sim...
-
Chapter
The Neutral Proteinases of Human Spleen
Hedin (1) reported that bovine spleen preparations showed proteolytic activity in both acidic and alkaline conditions. Many years later, the acidic-acting peptide hydrolases of this tissue were the subject of ...
