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Article
PTEN/MMAC1/TEP1 involvement in primary prostate cancers
The PTEN/MMAC1/TEP1 gene, located at 10q23.3, is a tumor suppressor gene responsible for the familial cancer syndromes Cowden disease and Bannayan-Zonana syndrome, and is commonly somatically mutated in several t...
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Article
Genetic aspects of prostate cancer
Despite its high incidence and mortality rate, the molecular mechanisms underlying the oncogenesis and progression of prostate cancer are still unclear. This review, based on recently published data, surveys ...
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Article
Molecular analysis of the FHIT gene in human prostate cancer
A variety of studies suggest that the FHIT gene, which encompasses the fragile site at 3p14.2, is a candidate tumor suppressor gene in several forms of human cancer. To determine whether the FHIT gene is alter...