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Article
Open AccessConditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice
Individuals with autism spectrum disorder (ASD) have a higher prevalence of social memory impairment. A series of our previous studies revealed that hippocampal ventral CA1 (vCA1) neurons possess social memory...
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Article
Open AccessVentromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice
Perception of fear induced by others in danger elicits complex vicarious fear responses and behavioral outputs. In rodents, observing a conspecific receive aversive stimuli leads to escape and freezing behavio...
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Article
Open AccessDisrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice
The ability to remember conspecifics is critical for adaptive cognitive functioning and social communication, and impairments of this ability are hallmarks of autism spectrum disorders (ASDs). Although hippoca...
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Article
Open AccessCharacterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal
The naked mole-rat (NMR) is a heterothermic mammal that forms eusocial colonies consisting of one reproductive female (queen), several reproductive males, and subordinates. Despite their heterothermy, NMRs pos...
