-
Article
Magnetic resonance imaging of acute intracerebral hematomas: In vivo and in vitro studies
The mechanisms causing unclear differentiation of ICH in the acute phase by MRI are discussed. The increase of the hemoglobin concentration in the hematoma, caused by loss of the plasma component directly afte...
-
Article
Symptomatic subependymoma with nuclear polymorphism
Two patients with symptomatic subependymomas are described. Histologically prominent cellular polymorphism was revealed. The existence of subependymoma with unusually marked polymorphism of the tumor cells sho...
-
Chapter
Prediction of the Reversibility of the Brain Stem Dysfunction in Head Injury Patients: MRI and Auditory Brain Stem Response Study
16 cases of head injury patients were examined by magnetic resonance imaging (MRI) and auditory brain stem response (ABR) simultaneously in acute stage in order to investigate the possibility of the prediction...
-
Chapter
Boron-, Gadolinium-Porphyrin Derivatives for Neutron Capture Therapy
New porphyrin derivatives conjugated with boron(B) or gadolinium(Gd) were developed to use as compound for neutron capture therapy in order to obtain tumor selective accumulation of B or Gd. In neutron capture...
-
Chapter
Clinical Protocol Using New Neutron Irradiation Facility (JRR4) at JAERI
After the shutdown of the former JRR2, which had been used for boron neutron capture therapy (BNCT) in clinical cases, in summer 1998 a new neutron irradiation facility (JRR4) was installed as a medical reacto...
-
Chapter
An Autopsy Report of a Glioblastoma Case after Boron Neutron Capture Therapy
Clinical trials of BNCT for glioblastoma have been underway around the World. In Japan, the new reactor JRR-4 has been now reconstructed especially for therapeutic irradiation. From the clinical point of view,...
-
Chapter and Conference Paper
Radiographic Results of Cemented Stem Revision in THA
Radiographic and clinical results of revision and rerevision total hip arthroplasties (THA) with cemented stem were reviewed over 2-year follow-up. Revision THA was performed in 57 hips at an average age of 61...
-
Chapter
In Vivo and In Vitro Uptake Study of Boronated Porphyrins for Neutron Capture Therapy
To improve boron neutron capture therapy (BNCT), a new tumor-seeking drug is required. Boronated porphyrins have been developed for boron carriers in boron neutron capture therapy (BNCT) with some positive res...
-
Chapter
Apoptosis of Tumor Cells in Response to Boron Neutron Capture Therapy
We examined the incidence of radiation-induced apoptosis in 9L gliosarcoma cells in response to gamma-ray irradiation (single doses of 1, 10, or 20Gy), neutron irradiation, and BNCT using BSH or boronated meta...
-
Chapter
Radiobiological Effects of Boronated Porphyrin (STA-BX909) Compared to BSH in Cultured Glioma Cell Line
Porphyrin is known as a tumor localizing agent that is clinically used in photo-dynamic therapy for cancers.1 Boronated porphyrins have also been developed2–7 and are now being investigated for possible clinical ...
-
Chapter
Cell Cycle Change of 9L Glioma Cell after in Vitro Boron Neutron Capture Therapy
Proliferating tumor cell progress through the phases of each cell cycle. Cell cycle change such as G2/M arrest is known to occur in tumor cells after γ ray radiation.1,2 However, cell cycle change of tumor cell a...
-
Chapter
The Advantage of Porphyrin for BNCT from the Point of View of Cell Cycle
The potential for using boronated porphyrins for BNCT have been reported by some groups.1–5 Our recent studies have also shown that porphyrin is one of the potential tumor targeting agents for BNCT.6,7 The tumor ...
-
Article
Tumor cell proliferation of hepatocellular carcinoma, with special reference to ultrasonographic findings and arterial vascularity by US angiography
To determine the clinical significance of tumor-cell proliferation in hepatocellular carcinoma (HCC), we investigated the relationship between tumor-cell proliferation evaluated by Ki-67 labeling index and ult...
-
Article
Localization of gelatinase activities in glioma tissues by film in situ zymography
Malignant gliomas are characterized by their invasiveness and angiogenesis, which are mediated by metalloproteinases (MMPs). In this study, localization of gelatinase activities in six cases of glioblastoma, t...
-
Article
Lignification and peroxidase in tension wood ofEucalyptus viminalis seedlings
Seedlings ofEucalyptus viminalis were grown for 50 days with their stems bent so tension wood would form. Every 10 days the lignin content, monomeric composition, and peroxidase activity in the tension wood were ...
-
Article
Myelopathy caused by tics in an adolescent, associated with T2 signal intensity changes of the spinal cord
Course: A 15-year-old boy who had suffered motor tics since age 9 developed progressive cervical myelopathy involving both his hands and his lower extremities. T2-weighted MRI revealed mild canal...
-
Article
Clinical review of the japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams
Our concept of boron neutron capture therapy (BNCT) is selective destruction of tumor cells using the heavy-charged particles yielded through10B(n, α)7Li reactions. To design a new protocol that employs epitherma...
-
Article
Clinical Review of the Japanese Experience with Boron Neutron Capture Therapy and A Proposed Strategy Using Epithermal Neutron Beams
Our concept of boron neutron capture therapy (BNCT) is selective destruction of tumor cells using the heavy-charged particles yielded through 10 B(n, α)7 Li reactions. To design a new protocol that employs epithe...
-
Article
Use of FDG-microPET for detection of small nodules in a rabbit model of pulmonary metastatic cancer
The performance of microPET using18F-FDG was evaluated in a rabbit model of hematogenous pulmonary metastatic cancer.
-
Article
Angiogenesis and antiangiogenic therapy for malignant gliomas
Angiogenesis is crucial to the growth of malignant gliomas. Therefore, antiangiogenic therapy represents a new, promising therapeutic modality for malignant gliomas. This study was designed to define the malig...
