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Article
Open AccessCell-compatible isotonic freezing media enabled by thermo-responsive osmolyte-adsorption/exclusion polymer matrices
During the long-term storage of cells, it is necessary to inhibit ice crystal formation by adding cryoprotectants. Non-cell-permeable cryoprotectants have high osmotic pressure which dehydrates cells, indirect...
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Article
Evaluation of newly designed flushing techniques for on-site remediation of arsenic-contaminated excavated debris
Excavated debris (soil and rock) contaminated with geogenic arsenic (As) is an increasing concern for regulatory organizations and construction stakeholders. Chelator-assisted soil flushing is a promising meth...
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Article
Large scale production of 64Cu and 67Cu via the 64Zn(n, p)64Cu and 68Zn(n, np/d)67Cu reactions using accelerator neutrons
Both 64Cu and 67Cu are promising radionuclides in nuclear medicine. Production yields of these radionuclides were quantified by irradiating 55.4 g of natural zinc with accelerator neutrons. Clinically suitable 64
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Article
Open AccessNano spin-diodes using FePt-NDs with huge on/off current ratio at room temperature
Spin transistors have attracted tremendous interest as new functional devices. However, few studies have investigated enhancements of the ON/OFF current ratio as a function of the electron spin behavior. Here,...
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Article
Open AccessShort-term change of carotid intima-media thickness after treatment of hyperglycemia in patients with diabetes: a cross-sectional study
The carotid artery intima-media thickness (CIMT) has been used as a predictor of cardiovascular events, but it remains unclear whether CIMT can change over the short term. We evaluated changes of CIMT in patie...
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Article
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection
Intratumoral hypoxia and hypoxia inducible factor-1α (HIF-1-α)-dependent CD39/CD73 ectoenzymes may govern the accumulation of tumor-protecting extracellular adenosine and signaling through A2A adenosine recept...
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The Hypoxia-adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment
In this chapter, we will focus on physiological regulators of activated immune cells in cancerous tissue microenvironments. This consideration started when we were contemplating the molecular mechanism that wo...
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Article
An interesting case with obese and ketosis-prone type 2 diabetes suggesting metformin action on the adipose tissue
We report a 63-year-old obese ketosis-prone diabetic woman who was being treated with metformin and a low dose of insulin. We performed two hyperinsulinemic-euglycemic clamp studies followed by an oral glucose...
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Article
Cold-loaded pain sensation test and current perception threshold for evaluating diabetic neuropathy
We previously designed and reported a simple new method (the cold-loaded pain sensation test) for quantitative evaluation of the function of small nerve fibers. In the study reported here, we investigated the ...
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Article
Targeting the hypoxia-adenosinergic signaling pathway to improve the adoptive immunotherapy of cancer
The recent approval by the FDA of cancer vaccines and drugs that blockade immunological negative regulators has further enhanced interest in promising approaches of the immunotherapy of cancer. However, the di...
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Article
Layer Transfer and Simultaneous Activation of Phosphorus Atoms in Silicon Films by Near-Infrared Semiconductor Diode Laser Irradiation
Layer transfer and simultaneous activation of phosphorus atoms in Si films induced by semiconductor diode laser (SDL) irradiation have been investigated. Phosphorus-doped a-Si films supported by columns on a s...
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Chapter
Methylxanthines, Inflammation, and Cancer: Fundamental Mechanisms
Methylxanthines are an integral part of everyday food and drink consumption even though the majority of humans do not identify them by their chemical name. The breakthrough in understanding the action(s) of me...
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Article
Open AccessCritical Role of Hypoxia and A2A Adenosine Receptors in Liver Tissue-Protecting Physiological Anti-Inflammatory Pathway
Whole body exposure of wild type control littermates and A2A adenosine receptor (A2AR) gene deleted mice to low oxygen containing inspired gas mixture allowed the investigation of the mechanism that controls i...
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Article
Open AccessFrom ‘Hellstrom Paradox–to anti-adenosinergic cancer immunotherapy
Cancer therapy by endogenous or adoptively transferred anti-tumor T cells is considered complementary to conventional cancer treatment by surgery, radiotherapy or chemotherapy. However, the scope of promising ...
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Article
Caveats and cautions for the therapeutic targeting of the anti-inflammatory A2 adenosine receptors
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Article
Unique incorporation behavior of amino acid-type surfactant into phospholipid vesicle membrane
The incorporation behavior of some anionic surfactants, including amino acid-type surfactants, on phospholipid vesicles was investigated. This was done by measuring the release of a vesicle-entrapped fluoresce...
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Article
Krafft temperature and enthalpy of solution of N-acyl amino acid surfactants and their racemic modifications: effect of the counter ion
The Krafft temperatures and enthalpies of solution of N-hexadecanoyl alaninate and valinate, and N-tetradecanoyl phenylalaninate were obtained from differential scanning calorimetry. The Krafft temperature of N-a...
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Article
Krafft temperature and enthalpy of solution of N-acyl amino acid surfactants and their racemic modifications: effect of the amino acid residue
The Krafft temperatures and the enthalpies of solution of six kinds of N-hexadecanoyl amino acid surfactant (Gly, Ala, Val, Leu, Ile, and Phe) were obtained from both solubility measurements and differential sca...
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Article
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage
Inappropriate or prolonged inflammation is the main cause of many diseases1; for this reason it is important to understand the physiological mechanisms that terminate inflammation in vivo2. Agonists for several G
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Article
Calorimetric Study of Micelle Formation in Polyethylene Glycol Monooctyl Ether Solution
The micellar solutions of polyethylene glycol monooctyl ethers C8Ej (j = 3,4,5) were investigated by employing the high-precision isothermal titration microcalorimeter at seven temperatures from 10° to 40°C. From...
