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Article
Open AccessMatched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study
Low serum selenium and altered tumour RNA expression of certain selenoproteins are associated with a poor breast cancer prognosis. Selenoprotein expression stringently depends on selenium availability, hence c...
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Article
Open AccessAuthor Correction: Validation of the BOADICEA model for predicting the likelihood of carrying pathogenic variants in eight breast and ovarian cancer susceptibility genes
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Article
Open AccessExtended genetic analysis and tumor characteristics in over 4600 women with suspected hereditary breast and ovarian cancer
Genetic screening for pathogenic variants (PVs) in cancer predisposition genes can affect treatment strategies, risk prediction and preventive measures for patients and families. For decades, hereditary breast...
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Article
Open AccessObesity-associated changes in molecular biology of primary breast cancer
Obesity is associated with an increased risk of develo** breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the bi...
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Article
Open AccessOvarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2
The distribution of ovarian tumour characteristics differs between germline BRCA1 and BRCA2 pathogenic variant carriers and non-carriers. In this study, we assessed the utility of ovarian tumour characteristics a...
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Article
Open AccessValidation of the BOADICEA model for predicting the likelihood of carrying pathogenic variants in eight breast and ovarian cancer susceptibility genes
BOADICEA is a comprehensive risk prediction model for breast and/or ovarian cancer (BC/OC) and for carrying pathogenic variants (PVs) in cancer susceptibility genes. In addition to BRCA1 and BRCA2, BOADICEA versi...
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Article
Open AccessMolecular characteristics of breast tumors in patients screened for germline predisposition from a population-based observational study
Pathogenic germline variants (PGVs) in certain genes are linked to higher lifetime risk of develo** breast cancer and can influence preventive surgery decisions and therapy choices. Public health programs of...
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Article
Open AccessRNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer
Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, su...
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Article
Open AccessSpatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions
In the past decades, transcriptomic studies have revolutionized cancer treatment and diagnosis. However, tumor sequencing strategies typically result in loss of spatial information, critical to understand cell...
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Article
Open AccessA search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients
The risk of breast cancer associated with CHEK2:c.1100delC is 2–threefold but higher in carriers with a family history of breast cancer than without, suggesting that other genetic loci in combination with CHEK2:c...
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Open AccessAuthor Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-23162-4
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Article
Open AccessCorrection to: Molecular analyses of triple-negative breast cancer in the young and elderly
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessDistinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer
Resistance to endocrine treatment in metastatic breast cancer is a major clinical challenge. Clinical tools to predict both drug resistance and possible treatment combination approaches to overcome it are lack...
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Article
Open AccessA case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identifi...
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Article
Open AccessMolecular analyses of triple-negative breast cancer in the young and elderly
Breast cancer in young adults has been implicated with a worse outcome. Analyses of genomic traits associated with age have been heterogenous, likely because of an incomplete accounting for underlying molecula...
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Article
Open AccessThe spatial RNA integrity number assay for in situ evaluation of transcriptome quality
The RNA integrity number (RIN) is a frequently used quality metric to assess the completeness of rRNA, as a proxy for the corresponding mRNA in a tissue. Current methods operate at bulk resolution and provide ...
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Article
Open AccessBreast cancer survival in Nordic BRCA2 mutation carriers—unconventional association with oestrogen receptor status
The natural history of breast cancer among BRCA2 carriers has not been clearly established. In a previous study from Iceland, positive ER status was a negative prognostic factor. We sought to identify factors tha...
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Article
Integrating spatial gene expression and breast tumour morphology via deep learning
Spatial transcriptomics allows for the measurement of RNA abundance at a high spatial resolution, making it possible to systematically link the morphology of cellular neighbourhoods and spatially localized gen...
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Article
Open AccessComprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Homologous recombination deficiency (HRD) is a defining characteristic in BRCA-deficient breast tumors caused by genetic or epigenetic alterations in key pathway genes. We investigated the frequency of BRCA1 prom...
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Article
Open AccessPrognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer
The extent and composition of the immune response in a breast cancer is one important prognostic factor for the disease. The aim of the current work was to refine the analysis of the humoral component of an im...
