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  1. No Access

    Article

    Unveiling the Protective Potential of Sugammadex against PTZ-Induced Epileptic Seizures in Mice: A Comprehensive Study on Oxidative Stress, Apoptosis, and Autophagy

    Sugammadex (SUG) is a modified γ-cyclodextrin molecule used in patients under general anesthesia to reverse the effects of neuromuscular blocking agents. Besides, recent studies have shown that SUG positively ...

    Mustafa Karademir, Aysegül Öztürk, Fatih Yulak, Mustafa Özkaraca… in Neurochemical Journal (2024)

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    Article

    Sugammadex Potentiation of Morphine Analgesia and Reduction of Opioid Tolerance Is Accompanied by Inhibition of Oxidative Stress and the NLRP3/IL-1β Signaling Pathway in the Rat Dorsal Root Ganglion

    Recent studies have shown that sugammadex’s effects on the nervous system are controversial and its effect on nociception, morphine analgesia and tolerance is still unclear. The current study aimed to examine ...

    Ahmet Sevki Taskiran, Onur Avci in Neurochemical Journal (2024)

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    Article

    Aspirin attenuates morphine antinociceptive tolerance in rats with diabetic neuropathy by inhibiting apoptosis in the dorsal root ganglia

    Morphine is a drug used in chronic pain such as diabetic neuropathy, but the development of tolerance to its antinociceptive effect is an important clinical problem. Aspirin is an analgesic and antiapoptotic d...

    Ercan Ozdemir, Onur Avcı, Zeynep Deniz Sahin Inan… in Metabolic Brain Disease (2023)

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    Article

    Metformin prevents morphine-induced apoptosis in rats with diabetic neuropathy: a possible mechanism for attenuating morphine tolerance

    Morphine is a drug of choice for the treatment of severe and chronic pain, but tolerance to the antinociceptive effect limits its use. The development of tolerance to morphine has recently been associated with...

    Onur Avci, Ercan Ozdemir… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2022)

  5. No Access

    Article

    The Anticonvulsant Effects of Alpha-2 Adrenoceptor Agonist Dexmedetomidine on Pentylenetetrazole-Induced Seizures in Rats

    Alpha2-adrenoreceptor (α2-AR) is a noradrenergic receptor that is frequently studied for modulation of seizure activity. However, the precise role of this receptor agonists in regulating seizure activity is still...

    Arzuhan Cetindag Ciltas, Ercan Ozdemir, Erkan Gumus… in Neurochemical Research (2022)

  6. No Access

    Article

    The effect of salmon calcitonin against glutamate-induced cytotoxicity in the C6 cell line and the roles the inflammatory and nitric oxide pathways play

    Recent evidence has shown that salmon calcitonin (sCT) has positive effects on the nervous system. However, its effect and mechanisms on glutamate-induced cytotoxicity are still unclear. The current experiment...

    Ahmet Sevki Taskiran, Merve Ergul in Metabolic Brain Disease (2021)

  7. No Access

    Article

    The role of nitric oxide in anticonvulsant effects of lycopene supplementation on pentylenetetrazole-induced epileptic seizures in rats

    Recent studies have shown that natural antioxidant compounds have positive effects on the nervous system. Lycopene, the red pigment in tomatoes, is one of the potent natural antioxidants, and is used as supple...

    Ahmet Sevki Taskiran, Yasar Tastemur in Experimental Brain Research (2021)

  8. No Access

    Article

    The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line

    Recent studies have shown that proton pump inhibitors have positive effects on the nervous system. However, its effect on epileptic seizure and neuronal damage are still unclear. In this study, it was aimed to...

    Ahmet Sevki Taskiran, Mustafa Ergul, Handan Gunes… in Cellular and Molecular Neurobiology (2021)