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Position switch of phenylthiazoles: novel compounds with promising anti-MRSA USA300
The discovery of novel antibacterial agents holds promise in mitigating the escalating threat of antimicrobial resistance (AMR). Guided by the structure-activity relationships (SAR) of our lead compound 1 against...
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Open AccessExploring the antimicrobial activity of Origanum majorana L. against the highly virulent multidrug-resistant Acinetobacter baumannii AB5075: UPLC-HRMS profiling with in vitro and in silico studies
The infamous multidrug-resistant (MDR) bacterium Acinetobacter baumannii is becoming a nightmare in intensive care units across the globe. Since there are now very few effective antimicrobial agents, it is necess...
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Open AccessNanobodies in the fight against infectious diseases: repurposing nature's tiny weapons
Nanobodies are the smallest known antigen-binding molecules to date. Their small size, good tissue penetration, high stability and solubility, ease of expression, refolding ability, and negligible immunogenici...
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Open AccessEvidence on the inhibitory effect of Brassica plants against Acinetobacter baumannii lipases: phytochemical analysis, in vitro, and molecular docking studies
Infections caused by Acinetobacter baumannii are becoming a rising public health problem due to its high degree of acquired and intrinsic resistance mechanisms. Bacterial lipases penetrate and damage host tissues...
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Open AccessThe Moraxella catarrhalis AdhC–FghA system is important for formaldehyde detoxification and protection against pulmonary clearance
Multidrug-resistant clinical isolates of Moraxella catarrhalis have emerged, increasing the demand for the identification of new treatment and prevention strategies. A thorough understanding of how M. catarrhalis
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Open AccessExpression and purification of hepatitis B surface antigen S from Escherichia coli; a new simple method
Hepatitis B is a liver disease primarily caused by hepatitis B virus (HBV) infection. It is distributed worldwide and associated with high mortality and morbidity rates. HBV infections can be avoided by the ad...
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Open AccessIdentification of a bacteriocin and its cognate immunity factor expressed by Moraxella catarrhalis
Bacteriocins are antimicrobial proteins and peptides ribosomally synthesized by some bacteria which can effect both intraspecies and interspecies killing.
