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  1. Article

    Open Access

    Facile adipocyte uptake and liver/adipose tissue delivery of conjugated linoleic acid-loaded tocol nanocarriers for a synergistic anti-adipogenesis effect

    Obesity is a major risk to human health. Adipogenesis is blocked by α-tocopherol and conjugated linoleic acid (CLA). However, their effect at preventing obesity is uncertain. The effectiveness of the bioactive...

    Ching-Yun Hsu, Chia-Chih Liao, Zih-Chan Lin, Ahmed Alalaiwe in Journal of Nanobiotechnology (2024)

  2. No Access

    Article

    Nanoencapsulation of Tea Catechins for Enhancing Skin Absorption and Therapeutic Efficacy

    Tea catechins are a group of flavonoids that show many bioactivities. Catechins have been extensively reported as a potential treatment for skin disorders, including skin cancers, acne, photoaging, cutaneous ...

    Ibrahim A. Aljuffali, Chih-Hung Lin, Shih-Chun Yang, Ahmed Alalaiwe in AAPS PharmSciTech (2022)

  3. Article

    Open Access

    Multifunctional lipid-based nanocarriers with antibacterial and anti‐inflammatory activities for treating MRSA bacteremia in mice

    Bacteremia-induced sepsis is a leading cause of mortality in intensive care units. To control a bacterial infection, an immune response is required, but this response might contribute to organ failure. Kidneys...

    Chia-Chih Liao, Huang-** Yu, Shih-Chun Yang in Journal of Nanobiotechnology (2021)

  4. No Access

    Article

    Sustained release and enhanced oral bioavailability of rivaroxaban by PLGA nanoparticles with no food effect

    The purpose of the currents study was to enhance bioavailability of rivaroxaban (RXB) and reduce the food effect. RXB loaded PLGA nanoparticles (RXB-PLGA-NPs) were prepared by emulsion solvent evaporation meth...

    Md. Khalid Anwer, Muqtader Mohammad in Journal of Thrombosis and Thrombolysis (2020)

  5. No Access

    Article

    Anticancer Efficacy of Self-Nanoemulsifying Drug Delivery System of Sunitinib Malate

    Sunitinib malate (SM) is reported as a weakly soluble drug in water due to its poor dissolution rate and oral bioavailability. Hence, in the current study, various “self-nanoemulsifying drug delivery systems (...

    Saad M. Alshahrani, Abdullah S. Alshetaili, Ahmed Alalaiwe in AAPS PharmSciTech (2018)