8 Result(s)
within
Agnieszka Zakrzewska
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Chapter
Interactions Between Volumes, Flows and Pressures in the Brain: Intracranial Pressure, Cerebral Perfusion Pressure, Cerebral Autoregulation and the Concept of Compensatory Reserve
The incidence of traumatic brain injury (TBI) has been increasing globally and is estimated at 27–69 million of new cases per year. It remains the main single cause of death in young people below 40 years of a...
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Article
Monitoring cerebrovascular reactivity in pediatric traumatic brain injury: comparison of three methods
To study three different methods of monitoring cerebral autoregulation in children with severe traumatic brain injury.
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Article
Open AccessAlterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics
The early detection of metastasis based on biomarkers in plasma may improve cancer prognosis and guide treatment. The aim of this work was to characterize alterations in metabolites of the arginine pathway, en...
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Article
Open AccessAFM-based detection of glycocalyx degradation and endothelial stiffening in the db/db mouse model of diabetes
Degradation of the glycocalyx and stiffening of endothelium are important pathophysiological components of endothelial dysfunction. However, to our knowledge, these events have not been investigated in tandem ...
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Article
Differential effects of liver steatosis on pharmacokinetic profile of two closely related hepatoselective NO-donors; V-PYRRO/NO and V-PROLI/NO
To analyze the effect of liver steatosis and obesity on pharmacokinetic profile of two structurally-related liver-selective NO-donors — V-PYRRO/NO and V-PROLI/NO.
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Article
Open AccessActivation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension
Pulmonary arterial hypertension (PAH) is associated with inflammatory response but it is unknown whether it is associated with alterations in NNMT activity and MNA plasma concentration. Here we examined change...
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Article
Towards a comprehensive endothelial biomarkers profiling and endothelium-guided pharmacotherapy
Endothelial dysfunction has prognostic, diagnostic and therapeutic significance in cardiovascular disease, but the endothelial phenotype is still not measured routinely to stratify the cardiovascular risk and ...
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Article
Detection of Spreading Depolarization with Intraparenchymal Electrodes in the Injured Human Brain
Spreading depolarization events following ischemic and traumatic brain injury are associated with poor patient outcome. Currently, monitoring these events is limited to patients in whom subdural electrodes can...
