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  1. No Access

    Article

    Insights into Intra Periodontal Pocket Pathogenesis, Treatment, In Vitro-In Vivo Models, Products and Patents, Challenges and Opportunity

    Periodontal disease is a multifactorial pathogenic condition involving microbial infection, inflammation, and various systemic complications. Here, a systematic and comprehensive review discussing key-points s...

    Sumel Ashique, Afzal Hussain, Tasneem Khan, Sejuti Pal, Mohd. Rihan… in AAPS PharmSciTech (2024)

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    Reference Work Entry In depth

    Role of Synbiotics in Inflammatory Lung Diseases

    The microbiome of human gut or lungs is a sophisticated ecology of bacterial strains that inhabits the respiratory and digestive systems. Over the course of millions of years, these microbes coevolved with the...

    Sumel Ashique, Shubneesh Kumar… in Synbiotics in Human Health: Biology to Dru… (2024)

  3. No Access

    Article

    HSPiP and QbD Program–Based Analytical Method Development and Validation to Quantify Ketoconazole in Dermatokinetic Study

    Ketoconazole (KTZ) is the most potential azole anti-mycotic drug. The quantification of KTZ from various layers of the skin after topical application of lipidic nanocarriers is critical. We addressed a sensitive,...

    Afzal Hussain, Mohhammad Ramzan, Mohammad A. Altamimi, Tahir Khuroo in AAPS PharmSciTech (2023)

  4. No Access

    Chapter

    Polymeric Micelles in the Delivery of Proteins

    Polymeric micelles (PM) developed in solution by self-assembling of amphiphilic polymers and represents an advanced tool to overcome several issues related to drug delivery like low aqueous solubility drug tha...

    Sumel Ashique, Ashish Garg, Afzal Hussain… in Polymeric Micelles: Principles, Perspectiv… (2023)

  5. Article

    Correction to: Formulation of Gelucire®-Based Solid Dispersions of Atorvastatin Calcium: In Vitro Dissolution and In Vivo Bioavailability Study

    Basmah N. Aldosari, Alanood S. Almurshedi, Iman M. Alfagih… in AAPS PharmSciTech (2022)

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  6. No Access

    Article

    In vitro release, ex vivo penetration, and in vivo dermatokinetics of ketoconazole-loaded solid lipid nanoparticles for topical delivery

    The study focused to evaluate and investigate optimized (using QbD) and novel ketoconazole (KTZ)-loaded solid lipid nanoparticles (KTZ-SLNs; 2% w/v KTZ) for enhanced permeation across skin. KTZ-SLNs were evalu...

    Mohhammad Ramzan, Samuel Gourion-Arsiquaud… in Drug Delivery and Translational Research (2022)

  7. No Access

    Article

    Experimental Solubility of Ketoconazole, Validation Models, and In vivo Prediction in Human Based on GastroPlus

    The study aimed to identify a suitable cosolvent + water mixture for subcutaneous (sub-Q) delivery of ketoconazole (KETO). The solubility was assessed for several dimethyl acetamide (DMA) + water mixtures at T = ...

    Afzal Hussain, Mohammad A. Altamimi, Sultan Alshehri, Syed Sarim Imam… in AAPS PharmSciTech (2021)

  8. No Access

    Article

    Formulation of Gelucire®-Based Solid Dispersions of Atorvastatin Calcium: In Vitro Dissolution and In Vivo Bioavailability Study

    Atorvastatin (ATV) is a poorly water-soluble drug that exhibits poor oral bioavailability. Therefore, present research was designed to develop ATV solid dispersions (SDs) to enhance the solubility, drug releas...

    Basmah N. Aldosari, Alanood S. Almurshedi, Iman M. Alfagih… in AAPS PharmSciTech (2021)

  9. No Access

    Article

    Experimental Solubility, Thermodynamic/Computational Validations, and GastroPlus-Based In Silico Prediction for Subcutaneous Delivery of Rifampicin

    We focused to explore a suitable solvent for rifampicin (RIF) recommended for subcutaneous (sub-Q) delivery [ethylene glycol (EG), propylene glycol (PG), tween 20, polyethylene glycol-400 (PEG400), oleic acid ...

    Wael A. Mahdi, Afzal Hussain, Mohammad A. Altamimi, Sultan Alshehri… in AAPS PharmSciTech (2021)

  10. Article

    Correction to: Pluronic-Coated Biogenic Gold Nanoparticles for Colon Delivery of 5-Fluorouracil: In vitro and Ex vivo Studies

    A Correction to this paper has been published: https://doi.org/10.1208/s12249-021-01954-7

    Wael A. Mahdi, Afzal Hussain, Mohd Ramzan, Abdul Faruk… in AAPS PharmSciTech (2021)

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  11. No Access

    Article

    Pluronic-Coated Biogenic Gold Nanoparticles for Colon Delivery of 5-Fluorouracil: In vitro and Ex vivo Studies

    The aim of the study was to prepare 5-fluorouracil (5-FU)-loaded biogenic gold nanoparticles with pluronic-based coating (PFGNPs), their optimization (full factorial predicted OBPN-1) and in vitro-ex vivo evaluat...

    Wael A. Mahdi, Afzal Hussain, Mohd Ramzan, Abdul Faruk… in AAPS PharmSciTech (2021)

  12. No Access

    Article

    Stimulatory Effects of Soluplus® on Flufenamic Acid β-Cyclodextrin Supramolecular Complex: Physicochemical Characterization and Pre-clinical Anti-inflammatory Assessment

    The present study demonstrates the solubility and dissolution of flufenamic acid (FLF)/β-cyclodextrin (β-CD)/Soluplus® supramolecular ternary inclusion complex. The binary and ternary inclusion complexes were ...

    Sultan Alshehri, Syed Sarim Imam, Mohammad A. Altamimi, Afzal Hussain… in AAPS PharmSciTech (2020)