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  1. Article

    Open Access

    Chronic whipworm infection exacerbates Schistosoma mansoni egg-induced hepatopathology in non-human primates

    Schistosomiasis continues to inflict significant morbidity and mortality in the tropical and subtropical regions of the world. The disease endemicity overlaps with the transmission of other parasitic diseases....

    Loc Le, Sabiha Khatoon, Paola Jiménez, Christopher Peterson… in Parasites & Vectors (2020)

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  2. No Access

    Protocol

    Testing of Schistosoma mansoni Vaccine Targets

    Vaccination has greatly reduced the burden of human diseases caused by infectious pathogens. Systematic development of vaccine targets requires established protocols to assess immunogenicity and efficacy of su...

    Weidong Zhang, Adebayo Molehin, Parth Patel, Eunjee Kim, Adam Peña… in Schistosoma mansoni (2020)

  3. Article

    Cross-species prophylactic efficacy of Sm-p80-based vaccine and intracellular localization of Sm-p80/Sm-p80 ortholog proteins during development in Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium

    Schistosomiasis remains a major global health problem. Despite large-scale schistosomiasis control efforts, clear limitations such as possible emergence of drug resistance and reinfection rates highlight the n...

    Adebayo J. Molehin, Souad R. Sennoune, Weidong Zhang, Juan U. Rojo… in Parasitology Research (2017)

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  4. No Access

    Article

    Longevity of Sm-p80-specific antibody responses following vaccination with Sm-p80 vaccine in mice and baboons and transplacental transfer of Sm-p80-specific antibodies in a baboon

    Based on data obtained using vaccine efficacy studies in mice, hamsters, and baboons, the credentials of Sm-p80 as a first tier vaccine candidate for schistosomiasis have been well established. Sm-p80-based va...

    Weidong Zhang, Gul Ahmad, Loc Le, Juan U. Rojo, Souvik Karmakar… in Parasitology Research (2014)

  5. No Access

    Article

    Simultaneous priming with DNA encoding Sm-p80 and boosting with Sm-p80 protein confers protection against challenge infection with Schistosoma mansoni in mice

    Prophylactic efficacy of Sm-p80 was tested in the mouse model using DNA priming and boosting with protein approach. However, the novelty of the approach utilized in this study is that both the DNA priming and ...

    Loc Le, Weidong Zhang, Souvik Karmakar, Gul Ahmad, Workineh Torben… in Parasitology Research (2014)

  6. Article

    Prime-boost and recombinant protein vaccination strategies using Sm-p80 protects against Schistosoma mansoni infection in the mouse model to levels previously attainable only by the irradiated cercarial vaccine

    Advent of an effective schistosome vaccine would contribute significantly toward reducing the disease spectrum and transmission of schistosomiasis. We have targeted a functionally important antigen, Sm-p80, as...

    Gul Ahmad, Weidong Zhang, Workineh Torben, Chad Haskins, Sue Diggs… in Parasitology Research (2009)

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  7. Article

    Experimental vaccines in animal models for schistosomiasis

    Considerable morbidity and mortality results from the affliction of an estimated 200 million people worldwide by several species of schistosomes; 779 million are exposed to the disease in 74 different countrie...

    Afzal A. Siddiqui, Gul Ahmad, Raymond T. Damian, Ronald C. Kennedy in Parasitology Research (2008)

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  8. No Access

    Article

    A cDNA encoding the highly immunodominant antigen of Strongyloides stercoralis: γ-subunit of isocitrate dehydrogenase (NAD+)

    A full length cDNA encoding the highly immunodominant 41 kDa antigen of Strongyloides stercoralis (P5), recognized by 83% of human patients [Siddiqui et al. (1997) Parasitol Res 83:655–658], is obtained. A clone...

    Afzal A. Siddiqui, Christy S. Stanley, Steven L. Berk in Parasitology Research (2000)

  9. No Access

    Article

    A cDNA encoding a nuclear hormone receptor of the steroid/thyroid hormone-receptor superfamily from the human parasitic nematode Strongyloides stercoralis

    A cDNA encoding a nuclear hormone receptor of the steroid/thyroid receptor superfamily was obtained from third-stage larvae(L3) of the parasitic roundworm Strongyloides stercoralis. A recombinant clone was isola...

    Afzal A. Siddiqui, Christy S. Stanley, Steven L. Berk… in Parasitology Research (2000)

  10. No Access

    Article

    Strongyloides stercoralis: identification of antigens in natural human infections from endemic areas of the United States

    Using Western-blot analysis, we identified eight immunodominant antigens (apparent molecular weights 96, 86, 75, 56, 41, 32, 28, and 26 kDa) of Strongyloides stercoralis in natural human infections. For this stu...

    Afzal A. Siddiqui, Nora M. Koenig, Michael Sinensky… in Parasitology Research (1997)

  11. No Access

    Article

    Radiolabeling ofNecator americanus third stage larvae with75Se-methionine

    Third stage larvae ofNecator americanus were radiolabeled with75Se-methionine by two methods. Larvae labeled in aqueous cultures contained 188 and 25 cpm per sheathed and ex-sheathed larva, respectively. Larvae l...

    Afzal A. Siddiqui, Y. Lei, Alan C. Fusco, B. Salafsky in Parasitology Research (1990)

  12. No Access

    Chapter

    Biomphalaria Glabrata, A Continuing Environmental Biodeteriogen: Alterations in the Levels of Some Hydrolases Following Schistosoma Mansoni Infection. 1. Phosphatases and N-Acetyl-Beta-D-Glucosaminidase

    The snail intermediate host of Schistosoma mansoni, has been considered the weakest link in the life cycle of this parasite. Chemical molluscicides are not specific for fresh water snails, and as a result all aqu...

    Afzal A. Siddiqui, Marwan M. Amarin, Betty R. Jones in Biodeterioration Research 2 (1989)