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IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells

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  1. Article

    Open Access

    An Fc variant with two mutations confers prolonged serum half-life and enhanced effector functions on IgG antibodies

    The pH-selective interaction between the immunoglobulin G (IgG) fragment crystallizable region (Fc region) and the neonatal Fc receptor (FcRn) is critical for prolonging the circulating half-lives of IgG molec...

    Sanghwan Ko, Sora Park, Myung Ho Sohn, Migyeong Jo… in Experimental & Molecular Medicine (2022)

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  2. Article

    Open Access

    Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA

    IK depletion leads to an aberrant mitotic entry because of chromosomal misalignment through the enhancement of Aurora B activity at the interphase. Here, we demonstrate that IK, a spliceosomal component, plays...

    Hye In Ka, Sunyi Lee, Sora Han, Ae Lee Jeong, Ji Young Park… in Cell Death Discovery (2020)

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  3. Article

    Open Access

    Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway

    Mutation of PPP2R1A has been observed at high frequency in endometrial serous carcinomas but at low frequency in ovarian clear cell carcinoma. However, the biological role of mutation of PPP2R1A in ovarian and en...

    Ae Lee Jeong, Sora Han, Sunyi Lee, Jeong Su Park, Yiling Lu… in Scientific Reports (2016)

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