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Article
Open AccessAn Fc variant with two mutations confers prolonged serum half-life and enhanced effector functions on IgG antibodies
The pH-selective interaction between the immunoglobulin G (IgG) fragment crystallizable region (Fc region) and the neonatal Fc receptor (FcRn) is critical for prolonging the circulating half-lives of IgG molec...
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Article
Open AccessDeubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA
IK depletion leads to an aberrant mitotic entry because of chromosomal misalignment through the enhancement of Aurora B activity at the interphase. Here, we demonstrate that IK, a spliceosomal component, plays...
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Article
IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells
Aurora B activation is triggered at the mitotic entry and required for proper microtubule-kinetochore attachment at mitotic phase. Therefore, Aurora B should be in inactive form in interphase to prevent aberra...
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Article
Open AccessPatient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway
Mutation of PPP2R1A has been observed at high frequency in endometrial serous carcinomas but at low frequency in ovarian clear cell carcinoma. However, the biological role of mutation of PPP2R1A in ovarian and en...
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Article
Interleukin-32β stimulates migration of MDA-MB-231 and MCF-7cells via the VEGF-STAT3 signaling pathway
IL-32 is known to play an important role in inflammatory and autoimmune disease responses. In addition to its role in these responses, IL-32 and its different isoforms have in recent years been implicated in t...
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Article
Herb mixture C5E aggravates doxorubicin-induced apoptosis of human breast cancer cell lines
A number of extracts from Asian traditional medicinal herbs have been successfully used as therapeutic agents against cancers. In this study we assessed the effect of C5E on the proliferation inhibition and ap...
