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  1. Article

    Open Access

    An Fc variant with two mutations confers prolonged serum half-life and enhanced effector functions on IgG antibodies

    The pH-selective interaction between the immunoglobulin G (IgG) fragment crystallizable region (Fc region) and the neonatal Fc receptor (FcRn) is critical for prolonging the circulating half-lives of IgG molec...

    Sanghwan Ko, Sora Park, Myung Ho Sohn, Migyeong Jo… in Experimental & Molecular Medicine (2022)

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  2. Article

    Open Access

    Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA

    IK depletion leads to an aberrant mitotic entry because of chromosomal misalignment through the enhancement of Aurora B activity at the interphase. Here, we demonstrate that IK, a spliceosomal component, plays...

    Hye In Ka, Sunyi Lee, Sora Han, Ae Lee Jeong, Ji Young Park… in Cell Death Discovery (2020)

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