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Open AccessDeubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA
IK depletion leads to an aberrant mitotic entry because of chromosomal misalignment through the enhancement of Aurora B activity at the interphase. Here, we demonstrate that IK, a spliceosomal component, plays...
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Article
IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells
Aurora B activation is triggered at the mitotic entry and required for proper microtubule-kinetochore attachment at mitotic phase. Therefore, Aurora B should be in inactive form in interphase to prevent aberra...